Diabetes
Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes. 2005 Jul;54(7):2219-26. Banday AA1, Marwaha A, Tallam LS, Lokhandwala MF.
ALS
Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.
Autoimmune
Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal models of oxidative damage and inflammation, such as experimental colitis and head trauma.
Parkinson's Disease
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease.
Cancer
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Tempol produced regression of Crohn’s Disease
Oxidative stress plays a significant role in the pathogenesis of inflammatory bowel disease. Endogenous antioxidants such as superoxide dismutase
Read MoreTempol improves cutaneous thermal hyperemia
New study from the University of Oregon publish in the American Journal of Physiology - Heart and Circulatory Physiology 2014 Mar 28. [Epub ahead of print]
Read MoreMitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes
Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial dysfunction and oxidative stress have a
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TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
Antioxidant, Immune, Inflammation, Mitochondria, Neurological, Oral Health, Oxidative Stress
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Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
ALS, Alzheimer's Disease, Antioxidant, Autoimmune, Dermatological, Immune, Metabolic Syndrome, Mitochondria, Muscular, Neurological, Neuropathy, Otology, Oxidative Stress, Parkinson's Disease, Psychiatric
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Tempol could resolve stress in the pathogenesis of organophosphate pesticides (Op) toxicity
Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S37-40. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Surajudeen YA1, Sheu RK1, Ayokulehin KM2, Olatunbosun AG1. 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 2Institute for Advanced Medical Research and Training, College of Medicine, University of […]
Agent Orange (TCDD), Cancer, Cardiovascular, Kidney, Oxidative Stress, Parkinson's Disease
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Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol
Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]
Agent Orange (TCDD), Antioxidant, Cancer, Cardiovascular, Hypertension, Mitochondria, Oxidative Stress
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Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?
Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]
Cancer, Immune, Metabolic Syndrome, Mitochondria, Oxidative Stress, Viral
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TEMPOL had a significant positive impact on body mass, atherosclerosis, hyperlipidaemia and inflammation
Atherosclerosis. 2015 May;240(1):234-41. The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice. Kim CH1, Mitchell JB2, Bursill CA3, Sowers AL4, Thetford A5, Cook JA6, van Reyk DM7, Davies MJ8. 1Free Radical Group, Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia; Faculty of Medicine, […]
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Tempol improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease
Synapse. 2015 Mar;69(3):128-38. 4-hydroxy tempo (Tempol) improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease. Sandhir R1, Mahajan N, Mehrotra A, Aggarwal A, Sunkaria A. 1Department of Biochemistry, Panjab University, Chandigarh, 160014, Punjab, India. Abstract Mitochondrial dysfunctions have been implicated in the progression of Huntington’s disease (HD). To date, several free radical scavengers […]
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Tempol suppresses EMF induced epigenetic changes
Mutat Res. 2012 Aug 30;747(1):138-41. Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration. Miyakoshi Y1, Kajihara C, Shimizu H, Yanagisawa H. 1Department of Public Health and Environmental Medicine, the Jikei University School of Medicine, Tokyo, Japan. Abstract A number of epidemiological studies have suggested that […]
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Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
Cancer, Cardiovascular, Immune, Mitochondria, Oxidative Stress
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Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells
Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]
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Tempol disrupts CtBP1 binding to Brca1
Oncogene. 2010 Dec 16;29(50):6603-8. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 Deng Y1, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. 1Department of Dermatology, University of Colorado, Denver, Aurora, CO 80045, USA. Abstract C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic […]
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Tempol inhibits mitochondrial superoxide: a novel specific anticancer treatment with reduced cytotoxic side effects
Antioxid Redox Signal. 2013 Aug 1;19(4):344-9. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR1, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor’ev IA, Dikalov SI. 1Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) […]
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Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.
PLoS One. 2014 Oct 1;9(10) Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Ahmed LA1, Shehata NI2, Abdelkader NF1, Khattab MM1. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Abstract BACKGROUND: Mitochondrial dysfunction […]
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SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
Mol Cancer Ther. 2012 Jan;11(1):87-97. SOD mimetics: a novel class of androgen receptor inhibitors that suppresses castration-resistant growth of prostate cancer. Thomas R1, Sharifi N. 1Department of Internal Medicine, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Abstract Advanced prostate cancer is the second leading cause of cancer-related deaths among […]
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Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]
Autoimmune, Brain Trauma, Immune, Inflammation, Neurological, Oxidative Stress, Viral
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Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
ALS, Autoimmune, Brain Trauma, Immune, Inflammation, Muscular, Neurological, Oxidative Stress, Viral
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SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
Antioxidant, Autoimmune, Dermatological, Immune, Inflammation, Mitochondria, Osteo, Oxidative Stress
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Tempol for SOD and catalase deficiency in psoriasis
Indian J Clin Biochem. 2010 Oct;25(4):388-92. Role of oxidative stress in various stages of psoriasis. Kadam DP1, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH. 1Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra India. Abstract Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous […]
Antioxidant, Autoimmune, Dermatological, Immune, Inflammation, Osteo, Oxidative Stress
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Tempol, losartan and EB1089 provided protection against DNA damaging effects of glucose and HIV.
Cell Signal. 2015 Mar;27(3):460-9. Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors. Rai P1, Singh T1, Lederman R1, Chawla A1, Kumar D1, Cheng K1, Valecha G1, Mathieson PW1, Saleem MA1, Malhotra A1, Singhal PC2. 1Department of Medicine, Feinstein Institute for Medical Research, North Shore LIJ Medical School, NY, USA; Department […]
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HIV Tat protein was prevented by antioxidant Tempol.
J Mol Cell Cardiol. 2011 Nov;51(5):876-80. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. Bai YL1, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL. 1Department of Pharmacology the State-Province Key Laboratories of Biomedicine-Pharmaceutics of […]
AIDS, Antioxidant, Immune, Inflammation, Parkinson's Disease, Viral
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Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Cancer Res. 2008 Mar 1;68(5):1601-8. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS1, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. 1Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA. Abstract Fanconi anemia (FA) is a […]
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Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.
Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure. Summary Skin cancer is the […]
Anti-aging, Antioxidant, Cancer, Dermatological, Immune, Oxidative Stress, Xeroderma Pigmentosum
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TEMPOL for Cancer
TEMPOL for Cancer– Why Treat Fibrocystic Change? Jan 11, 2015 Peter H Proctor, PhD, MD TEMPOL is a small-molecule “SOD-mimetic”, effective in a variety of experimental cancer models, both in vivo and in vitro. Tracing back to the Warburg effect, its putative mechanism of action is destruction of reactive oxygen species (ROS). These drive the […]
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Tempol restores erectile dysfunction in diabetic models
J Urol. 2009 Nov;182(5):2518-25. Restoring erectile function by antioxidant therapy in diabetic rats. Hirata H1, Kawamoto K, Kikuno N, Kawakami T, Kawakami K, Saini S, Yamamura S, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, California 94121, USA. Abstract PURPOSE: Diabetes mediates an increase in reactive oxygen […]
Anti-aging, Antioxidant, Diabetes, Erectile Dysfunction, Oxidative Stress, Peyronie's Disease, Sexual Dysfunction
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Tempol restores erectile function in diabetes-induced impotence.
Int J Impot Res. 2009 Nov-Dec;21(6):348-55. Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. Kawakami T1, Urakami S, Hirata H, Tanaka Y, Nakajima K, Enokida H, Shiina H, Ogishima T, Tokizane T, Kawamoto K, Miura K, Ishii N, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs […]
Diabetes, Erectile Dysfunction, Ischemia, Oxidative Stress, Peyronie's Disease, Sexual Dysfunction
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Mitochondrial antioxidants Tempol and EUK-134 effect in neurodegenerative diseases without the need of liposomes.
Eur J Pharmacol. 2002 Jul 5;447(2-3):155-61. Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases? Dessolin J1, Schuler M, Quinart A, De Giorgi F, Ghosez L, Ichas F. 1European Institute of Chemistry and Biology and INSERM E.9929, Université Victor Segalen-Bordeaux 2, 33076 Bordeaux cedex, France. Abstract Mitochondria are the major […]
ALS, Alzheimer's Disease, Antioxidant, Brain Trauma, Neurological, Oxidative Stress, Parkinson's Disease
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Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]
ALS, Antioxidant, Brain Trauma, Inflammation, Metabolic Syndrome, Mitochondria, Neurological, Parkinson's Disease
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Benefits of losartan and tempol in renal inflammation by hypernatremia.
Free Radic Res. 2015 Apr;49(4):383-96. Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Della Penna SL1, Rosón MI, Toblli JE, Fernández BE. 1Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Argentina. Abstract The body regulates plasma sodium levels […]
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Tempol diminishes cocaine-induced oxidative damage
Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]
Addiction, Antioxidant, Brain Trauma, Neurological, Oxidative Stress
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Polymorphisms in superoxide dismutase genes in autism spectrum disorder.
Autism Res. 2014 Feb;7(1):138-44. Rare single nucleotide polymorphisms in the regulatory regions of the superoxide dismutase genes in autism spectrum disorder. Kovač J1, Macedoni Lukšič M, Trebušak Podkrajšek K, Klančar G, Battelino T. 1Department of Endocrinology, Diabetes and Metabolic Diseases, UMC Ljubljana, University Children’s Hospital, Ljubljana, Slovenia. Abstract Oxidative stress is suspected to be one […]
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Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]
Anti-aging, Antioxidant, Brain Trauma, Diabetes, Neurological, Oxidative Stress
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Tempol ameliorates ROS and apnea-induced hypertension.
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2971-6. Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Troncoso Brindeiro CM1, da Silva AQ, Allahdadi KJ, Youngblood V, Kanagy NL. 1Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA. Abstract In clinical studies, sleep apnea is associated with hypertension, oxidative […]
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Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.
Am J Respir Cell Mol Biol. 2012 Feb;46(2):139-48. Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Skelly JR1, Edge D, Shortt CM, Jones JF, Bradford A, O’Halloran KD. 1Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. Abstract Respiratory muscle dysfunction is implicated in the […]
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Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]
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The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]
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Investigation of antioxidant enzymes in children with autistic disorder.
Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):341-3. Investigation of antioxidant enzymes in children with autistic disorder. Yorbik O1, Sayal A, Akay C, Akbiyik DI, Sohmen T. 1GATA Child and Adolescent Psychiatry Department, Etlik, Ankara, Turkey. Abstract Impaired antioxidant mechanisms are unable to inactivate free radicals that may induce a number of pathophysiological processes and result […]
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Oxidative stress in autism.
Pathophysiology. 2006 Aug;13(3):171-81. Oxidative stress in autism. Chauhan A1, Chauhan V. 1NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. Abstract Autism is a severe developmental disorder with poorly understood etiology. Oxidative stress in autism has been studied at the membrane level and also by measuring products […]
ADHD/Autism, Antioxidant, Brain Trauma, Neurological, Oxidative Stress
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Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation.
Biol Trace Elem Res. 2011 Oct;143(1):58-65. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Meguid NA1, Dardir AA, Abdel-Raouf ER, Hashish A. 1Department of Research on Children with Special Needs, National Research Center, Tahrir St, Cairo, Egypt. Abstract Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and […]
ADHD/Autism, Antioxidant, Brain Trauma, Neurological, Oxidative Stress
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Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening.
J Biol Chem. 2003 Feb 28;278(9):6824-30. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. Serra V1, von Zglinicki T, Lorenz M, Saretzki G. 1Institute of Pathology and Research Laboratory Cardiology, Charité Hospital, D-10098 Berlin, Germany. Abstract There is good evidence that telomere shortening acts as a biological clock in […]
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Aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by Tempol and Apocynin.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]
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WR-1065 and Tempol protected MOLT-3 cells against specific types of AZT-induced DNA damage.
Environ Mol Mutagen. 2014 Aug;55(7):566-72. Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and Tempol. Olivero OA1, Ongele MO, Braun HM, Marrogi A, Divi K, Mitchell JB, Poirier MC. 1Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Abstract The cytokinesis-block […]
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The mitochondrion: a perpetrator of acquired hearing loss.
Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]
Anti-aging, Antioxidant, Mitochondria, Otology, Oxidative Stress
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Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.
Cancer Lett. 2014 Oct 28;353(2):248-57 Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol. Georgakilas AG1, Redon CE2, Ferguson NF3, Kryston TB3, Parekh P2, Dickey JS4, Nakamura AJ5, Mitchell JB6, Bonner WM2, Martin OA7. 1Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, […]
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A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss.
Mech Ageing Dev. 2013 Jul-Aug;134(7-8):298-306. A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. Nolan LS1, Cadge BA, Gomez-Dorado M, Dawson SJ. 1Centre for Auditory Research, Ear Institute, University College London, 332 Gray’s Inn Road, London WC1X 8EE, UK. Abstract Genetic variation in superoxide dismutase 2 (SOD2) is […]
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The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea.
Hear Res. 2006 Apr;214(1-2):1-6. The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea. Murashita H1, Tabuchi K, Hoshino T, Tsuji S, Hara A. 1Department of Otolaryngology, Tsukuba University Hospital, Tsukuba, Japan. Abstract Oxygen free radicals have been implicated in the pathogenesis of acoustic injury of the cochlea. […]
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The role of redox balance in vascular dysfunction and chronic obstructive pulmonary disease.
Hypertension. 2014 Mar;63(3):459-67. Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance. Ives SJ1, Harris RA, Witman MA, Fjeldstad AS, Garten RS, McDaniel J, Wray DW, Richardson RS. 1VA Medical Center Bldg 2, Rm 1D25, 500 Foothill Dr, Salt Lake City, UT 84148. Abstract Chronic obstructive pulmonary disease (COPD) is characterized by […]
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SOD SNPs linked to lung function, bronchial responsiveness and pulmonary disease.
Eur Respir J. 2009 May;33(5):986-92. Superoxide dismutases, lung function and bronchial responsiveness in a general population. Siedlinski M1, van Diemen CC, Postma DS, Vonk JM, Boezen HM. 1Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands. Abstract Oxidative stress is an important causative factor in the onset and progression of smoking-related lung diseases, such […]
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Lecithinized superoxide dismutase as a drug for idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
Yakugaku Zasshi. 2014;134(1):69-76. Development of lecithinized superoxide dismutase as a drug for IPF [Article in Japanese] Mizushima T1. 1Department of Analytical Chemistry, Faculty of Pharmacy, Keio University. Abstract Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The […]
Antioxidant, Asthma, Inflammation, Oxidative Stress, Pulmonary
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SOD protects against oxidative stress caused by cisplatin.
Acta Otolaryngol. 2010 Apr;130(4):453-7. Endogenous protection against oxidative stress caused by cisplatin: role of superoxide dismutase. González-García JA1, Nevado J, García-Berrocal JR, Sánchez-Rodríguez C, Trinidad A, Sanz R, Ramírez-Camacho R. 1Servicio de Otorrinolaringología, Instituto Oncológico Kutxa-Onkologikoa, Paseo Dr Begiristain 119, San Sebastián, Guipúzcoa. Abstract CONCLUSION: The administration of cisplatin induces the activation of superoxide dismutase […]
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Protective effect of tempol and Nω-nitro-L-arginine methyl ester on acoustic injury,
J Pharmacol Sci. 2010;114(1):50-62. Mechanism underlying the protective effect of tempol and Nω-nitro-L-arginine methyl ester on acoustic injury: possible involvement of c-Jun N-terminal kinase pathway and connexin26 in the cochlear spiral ligament. Nagashima R1, Yamaguchi T, Tanaka H, Ogita K. 1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, Japan. Abstract […]
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Creatine and tempol attenuate noise-induced hearing loss.
Brain Res. 2007 May 7;1148:83-9. Creatine and tempol attenuate noise-induced hearing loss. Minami SB1, Yamashita D, Ogawa K, Schacht J, Miller JM. 1Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA. Abstract To define the role of free radical formation and potential energy depletion in noise induced hearing […]
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Tempol, NAC and pioglitazone all restored cerebrovascular reactivity in aged Alzheimer’s disease transgenic mice.
J Neurosci. 2008 Sep 10;28(37):9287-96. Complete rescue of cerebrovascular function in aged Alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. Nicolakakis N1, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. 1Laboratory of Cerebrovascular Research, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. Abstract […]
Alzheimer's Disease, Anti-aging, Antioxidant, Brain Trauma, Inflammation, Ischemia, Neurological, Oxidative Stress, Parkinson's Disease
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SOD and mitochondria quality control in ALS.
Brain Res. 2015 May 14 Exploring new pathways of neurodegeneration in ALS: The role of mitochondria quality control. Palomo GM1, Manfredi G2. 1Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United States. 2Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United […]
ALS, Anti-aging, Antioxidant, Brain Trauma, Mitochondria, Neurological, Oxidative Stress, Parkinson's Disease
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Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.
Redox Biol. 2014;3:88-99. Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall. Liu Z1, Gou Y2, Zhang H3, Zuo H1, Zhang H4, Liu Z5, Yao D6. 1Internal Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 2Department of Neurology, Wuhan No. 1 Hospital, #215 Zhongshan […]
Anti-aging, Antioxidant, Cardiovascular, Inflammation, Mitochondria, Oxidative Stress
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SOD2 and GSH are critical for the cellular antioxidant defense in neurodegenerative diseases and acute brain disorders.
Neurochem Int. 2015 Jan 6. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Ruszkiewicz J1, Albrecht J2. 1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. 2Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. Abstract Oxidative and nitrosative stress […]
ALS, Alzheimer's Disease, Anti-aging, Antioxidant, Brain Trauma, Inflammation, Mitochondria, Neurological, Oxidative Stress, Parkinson's Disease
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Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]
ALS, Antioxidant, Brain Trauma, Inflammation, Metabolic Syndrome, Mitochondria, Neurological, Parkinson's Disease
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MnSOD, ROS, mitochondria, oxidative stress diseases and aging, superoxide theory
J Clin Biochem Nutr. 2015 Jan;56(1):1-7. A mitochondrial superoxide theory for oxidative stress diseases and aging. Indo HP1, Yen HC2, Nakanishi I3, Matsumoto K3, Tamura M4, Nagano Y4, Matsui H4, Gusev O5, Cornette R6, Okuda T6, Minamiyama Y7, Ichikawa H8, Suenaga S9, Oki M10, Sato T9, Ozawa T11, Clair DK12, Majima HJ13. 1Department of […]
Anti-aging, Antioxidant, Brain Trauma, Mitochondria, Oxidative Stress
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Tempol may protect tissue around the base of the cornea.
J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]
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Involvement of peroxynitrite free radicals in retinal neurotoxicity.
Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]
Anti-aging, Antioxidant, Brain Trauma, Mitochondria, Neurological, Ocular
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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.
Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]
Anti-aging, Antioxidant, Brain Trauma, Diabetes, Ocular, Oxidative Stress
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Tempol mitigates C-reactive protein induced retinal damage.
Invest Ophthalmol Vis Sci. 2008 May;49(5):2053-60. C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Nagaoka T1, Kuo L, Ren Y, Yoshida A, Hein TW. 1Department of Ophthalmology, Scott & White Eye Institute, Temple, TX 76504, USA. Abstract PURPOSE: Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated […]
Antioxidant, Diabetes, Mitochondria, Ocular, Oxidative Stress
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Tempol and Vitamin C provide a potential novel treatment strategy for age-related macular degeneration.
Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells. Lau LI1, Chiou SH, Liu CJ, Yen MY, Wei YH. 1Institute of Clinical Medicine, School ofMedicine, National Yang-Ming University, Taipei, Taiwan. Abstract PURPOSE: Genetic variation in complement factor H […]
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Tempol and caspase inhibition reduced the production of ROS in glaucoma.
Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA. Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]
Antioxidant, Brain Trauma, Mitochondria, Ocular, Oxidative Stress
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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]
Angiogenisis, Anti-aging, Antioxidant, Brain Trauma, Ischemia, Ocular
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TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.
Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]
Angiogenisis, Anti-aging, Antioxidant, Brain Trauma, Ocular, Oxidative Stress
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Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model.
Toxicol Sci. 2012 Oct;129(2):411-20. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Solesio ME1, Saez-Atienzar S, Jordán J, Galindo MF. 1Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Abstract In the present study, the activation of autophagy and its interaction with the mitochondrial fission machinery was investigated in an experimental model […]
ALS, Alzheimer's Disease, Antioxidant, Brain Trauma, Inflammation, Mitochondria, Oxidative Stress, Parkinson's Disease
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Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme.
J Biol Chem. 2014 Oct 31;289(44):30690-701. Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme. Coelho FR1, Iqbal A1, Linares E1, Silva DF1, Lima FS1, Cuccovia IM1, Augusto O2. 1From the Departamento de Bioquímica, Instituto de Química, Universidade de São […]
ALS, Antioxidant, Brain Trauma, Inflammation, Mitochondria, Neurological, Parkinson's Disease
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The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.
Free Radic Biol Med. 2014 Dec;77:168-82. The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke. Dohare P1, Hyzinski-García MC1, Vipani A1, Bowens NH1, Nalwalk JW1, Feustel PJ1, Keller RW Jr1, Jourd’heuil D2, Mongin AA3. 1Center for Neuropharmacology and Neuroscience, Albany […]
Anti-aging, Antioxidant, Brain Trauma, Inflammation, Ischemia, Neurological, Oxidative Stress, Parkinson's Disease
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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Pharmacol Res. 2014 Mar;81:91-102. Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD). Impellizzeri D1, Esposito E1, Attley J2, Cuzzocrea S3. 1Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. 2Prismic Pharmaceuticals, Scottsdale, AZ, USA. 3Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno […]
Antioxidant, Hypertension, Inflammation, Kidney, Oxidative Stress, Renal
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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Circulation. 2015 Jan 20;131(3):289-99. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Gibson CC1, Zhu W1, Davis CT1, Bowman-Kirigin JA1, Chan AC1, Ling J1, Walker AE1, Goitre L1, Delle Monache S1, Retta SF1, Shiu YT1, Grossmann AH1, Thomas KR1, Donato AJ1, Lesniewski LA1, Whitehead KJ1, Li DY2. 1From the Program in […]
Angiogenisis, Antioxidant, Brain Trauma, Cardiovascular, Inflammation, Ischemia, Neurological, Oxidative Stress
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Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.
J Biol Chem. 2015 Mar 17. Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1. Bhattacharyya S1, Feferman L2, Tobacman JK3. 1University of Illinois at Chicago, United States 2University of Illinois at Chicago and Jesse Brown VA Medical Center, United States. 3University of Illinois at Chicago and Jesse Brown […]
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Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress.
Hypertension. 2015 Mar 2. Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress. Banday AA1, Lokhandwala MF2. 1From the Heart and Kidney Institute, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX. 2From the Heart and Kidney Institute, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of […]
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Antihypertensive effect of mitochondria-targeted proxyl nitroxides.
Redox Biol. 2015;4:355-62. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Dikalova AE1, Kirilyuk IA2, Dikalov SI3. 1Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. 2Novosibirsk Institute of Organic Chemistry, Lavrentieva 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia. 3Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. […]
Antioxidant, Cardiovascular, Hypertension, Inflammation, Oxidative Stress
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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]
Angiogenisis, Anti-aging, Antioxidant, Cardiovascular, Hypertension, Inflammation, Ischemia, Oxidative Stress
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Tempol protects blood proteins and lipids against peroxynitrite-mediated oxidative damage.
Exp Biol Med (Maywood). 2015 Jan;240(1):109-12. Tempol protects blood proteins and lipids against peroxynitrite-mediated oxidative damage. Mustafa AG1, Bani-Ahmad MA2, Jaradat AQ2, Allouh MZ3. 1Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. 2Department of Medical Laboratories, Faculty of Allied Medical Sciences, Jordan University of Science and Technology, Irbid […]
Antioxidant, Cardiovascular, Hypertension, Inflammation, Ischemia, Oxidative Stress
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Tempol protects human lymphocytes from genotoxicity induced by cisplatin.
Int J Clin Exp Med. 2014 Apr 15;7(4):982-8 Tempol protects human lymphocytes from genotoxicity induced by cisplatin. Khabour OF1, Alzoubi KH2, Mfady DS1, Alasseiri M1, Hasheesh TF1. 1Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology Irbid, Jordan. 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of […]
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Antioxidant defense capacity in scleroderma patients.
Clin Chem Lab Med. 2008;46(6):836-41. Antioxidant defense capacity in scleroderma patients. Sfrent-Cornateanu R1, Mihai C, Stoian I, Lixandru D, Bara C, Moldoveanu E. 1Department of Physiopathology and Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania. Abstract BACKGROUND: Oxidative stress is associated with scleroderma (systemic sclerosis) and is supposed to favor disease progression by […]
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The conservative treatment of Peyronie’s disease with orgotein
Khirurgiia (Sofiia). 1989;42(6):57-9. The conservative treatment of Peyronie’s disease with orgotein. [Article in Bulgarian] Ianev V, Tsvetkov D. Abstract Results are analyzed of treatment of patients with induratio penis plastica by local application of orgotein. Fifteen patients with clinically manifest disease were the subject of this study; 4-8 mg Orgotein bulk was applied once a […]
Antioxidant, Dermatological, Oxidative Stress, Peyronie's Disease
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Orgotein in the treatment of plastic induration of the penis (Peyronie’s disease).
Int Urol Nephrol. 1993;25(2):169-72. Orgotein in the treatment of plastic induration of the penis (Peyronie’s disease). Primus G1. 1Department of Urology, LKH, Graz, Austria. Abstract Eighteen patients with Peyronie’s disease have been treated with the anti-inflammatory metalloprotein Orgotein, which exhibits a pronounced superoxide dismutase activity. Only patients with severe symptoms were selected. The drug was […]
Autoimmune, Dermatological, Oxidative Stress, Peyronie's Disease, Wound Healing
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Intrathecal orgotein.
Int J Clin Pharmacol Res. 1985;5(1):59-62. Intrathecal orgotein. Lund-Olesen K. Abstract During the period 1971-78, 133 intrathecal injections of orgotein or superoxide dismutase have been given, mostly to patients with multiple sclerosis. Evaluation of the effect was deficient but the impression was that of improvement and 45% of the 58 patients with multiple sclerosis requested […]
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Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma.
J Invest Dermatol. 2004 Mar;122(3):594-601. Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma. Nagai M1, Hasegawa M, Takehara K, Sato S. 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Abstract Abnormal production of reactive oxygen species (ROS) induces tissue damage and superoxide dismutase (SOD) that converts superoxide radicals […]
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Topical application of superoxide dismutase cream.
Drugs Exp Clin Res. 1991;17(2):127-31. Topical application of superoxide dismutase cream. Mizushima Y1, Hoshi K, Yanagawa A, Takano K. 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan. Abstract A superoxide dismutase (SOD) cream containing 0.6 mg/ml of bovine SOD was prepared. It was applied locally onto the skin and mucosal lesions […]
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Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.
Acta Physiol Scand Suppl. 1980;492:59-65. Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase. Emerit I, Michelson AM. Abstract Increased chromosome breakage is observed in lymphocyte cultures from patients with so-called autoimmune diseases also in the animal model, the NZB mouse. A clastogenic agent was detected in the serum of […]
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Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors.
J Heart Lung Transplant. 2008 Aug;27(8):890-7. doi: 10.1016/j.healun.2008.05.019. Epub 2008 Jul 3. Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors. Hodyc D1, Hnilickova O, Hampl V, Herget J. 1Department of Physiology, Second Medical School, Charles University of Prague, Prague, Czech Republic. BACKGROUND: Lungs retrieved […]
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TEMPOL-H for Fibrocystic Breast Disease– Case Report.
SFRBM (Society For Free Radical Biology and Medicine) Meeting, Nov. 20-24, 2013, San Antonio, TX Peter Proctor, Donna RollingProctor ABSTRACT Variably presenting with painful cysts and mastodynia, fibrocystic disease of breast (FD) affects 30-40% of women. FD complicates breast cancer diagnosis by requiring work-up of lumps to rule-out malignancy and by obscuring malignant lesions. Although […]
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Low Superoxide Dismutase and Catalase Activities and their Correlation with Malondialdehyde In Schizophrenic Patients
Indian J Clin Biochem. 2004 Jul;19(2):114-8. Superoxide Dismutase and Catalase Activities and their Correlation with Malondialdehyde in Schizophrenic Patients. Rukmini MS1, D’Souza B, D’Souza V. 1Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, 575 004 Mangalore, India. Abstract Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy […]
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A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.
Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]
Alopecia, Angiogenisis, Antioxidant, Brain Trauma, Cancer, Dermatological, Immune, Inflammation, Radiation Protection, Xeroderma Pigmentosum
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Therapeutic and Clinical Applications of Nitroxide Compounds
Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]
Alopecia, ALS, Alzheimer's Disease, Angiogenisis, Anti-aging, Antioxidant, Brain Trauma, Cancer, Dermatological, Hypertension, Immune, Inflammation, Ischemia, Metabolic Syndrome, Neurological, Oxidative Stress, Parkinson's Disease, Radiation Protection, Xeroderma Pigmentosum
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Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection. [Article in Polish]
Postepy Hig Med Dosw (Online). 2011 Feb 2;65:46-54. [Article in Polish] Tabaczar S¹, Talar M, Gwoździński K. Abstract Nitroxides as stabile organic radicals were used initially as spin labels in spectroscopy of electron paramagnetic resonance (EPR) with respect to parameters such as pH of an intercellular environment, oxygenation of cells and tissues, fluidity of biological membranes, […]
Anti-aging, Antioxidant, Cancer, Dermatological, Inflammation, Oxidative Stress, Radiation Protection, Wound Healing
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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Pharmacol Res. 2014 Mar;81:91-102. Impellizzeri D¹, Esposito E¹, Attley J², Cuzzocrea S³. ¹Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. ²Prismic Pharmaceuticals, Scottsdale, AZ, USA. ³Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy; Manchester Biomedical Research Centre, Manchester Royal […]
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Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome.
Brain Dev. 2005 Jan;27(1):34-8. Hayashi M¹, Araki S, Kohyama J, Shioda K, Fukatsu R. Abstract Xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are caused by a genetic defect of nucleotide excision repair mechanisms, showing cutaneous hypersensitivity to sunlight and progressive neurological disturbances. The cause of neurological abnormalities has yet to be clarified and […]
Antioxidant, Brain Trauma, Dermatological, Inflammation, Oxidative Stress, Xeroderma Pigmentosum
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Oxidative stress in developmental brain disorders.
Neuropathology. 2009 Feb;29(1):1-8. Hayashi M¹. ¹Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. Abstract Oxidative stress is one of the predisposing factors in adult neurological disorders. We have examined the involvement of oxidative stress in child-onset neurodegenerative disorders, and here we review the findings from our analysis. In cases of Cockayne syndrome, […]
ADHD/Autism, Alzheimer's Disease, Antioxidant, Brain Trauma, Dermatological, Inflammation, Neurological, Oxidative Stress, Parkinson's Disease, Xeroderma Pigmentosum
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Possible protective effect by SOD on UV damage in xeroderma pigmentosum (XP)
J Invest Dermatol. 1989 Oct;93(4):506-10. Reduced superoxide dismutase activity in xeroderma pigmentosum fibroblasts. Nishigori C¹, Miyachi Y, Imamura S, Takebe H. ¹Department of Dermatology, Faculty of Medicine, Kyoto University, Japan. Abstract This study was performed in order to assess the possible protective effect of superoxide dismutase (SOD) on ultraviolet (UV) damage in xeroderma pigmentosum […]
Antioxidant, Cancer, Dermatological, Immune, Inflammation, Oxidative Stress, Xeroderma Pigmentosum
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New Treatment Method to Help Women Suffering From Fibrocystic Disease
FOR IMMEDIATE RELEASE August 19, 2014 Fibrocystic disease may affect up to 50 percent of all women (INDIANAPOLIS, Ind.) –A new patent has been issued for a method that uses the SOD-mimetic agent TEMPOL to treat fibrocystic disease of the breast (FD). Approximately 20 percent of women suffering from FD, which is more commonly known […]
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Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Hum Mol Genet. 2005 Jun 15;14(12):1699-708. Epub 2005 May 11. Erker L¹, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A. ¹Department of Pediatrics, UCSD School of Medicine, La Jolla, CA Abstract We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient […]
Angiogenisis, Antioxidant, Cancer, Immune, Inflammation, Oxidative Stress
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Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease.
Biochem Pharmacol. 2005 Nov 1;70(9):1371-81. Liang Q¹, Smith AD, Pan S, Tyurin VA, Kagan VE, Hastings TG, Schor NF. ¹Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA Abstract TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) is a stable nitroxyl antioxidant. Previous studies have suggested that TEMPOL is protective in acute disorders thought to involve reactive oxygen species (ROS), such as […]
Antioxidant, Brain Trauma, Inflammation, Ischemia, Mitochondria, Neurological, Oxidative Stress, Parkinson's Disease
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Nitroxide stable radical suppresses autoimmune uveitis in rats.
Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]
Antioxidant, Autoimmune, Brain Trauma, Digestive, Immune, Inflammation, Oxidative Stress
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Tempol Moderately Extends Survival in a hSOD1G93A ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1G93A Forms
PLoS One. 2013; 8(2): e55868. Linares E¹, Seixas LV, dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O. ¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms […]
ALS, Antioxidant, Inflammation, Mitochondria, Neurological, Oxidative Stress
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Tempol reduces oxidative stress, improves insulin sensitivity.
Diabetes. 2005 Jul;54(7):2219-26. Banday AA¹, Marwaha A, Tallam LS, Lokhandwala MF. ¹Heart and Kidney Institute, University of Houston, Houston, Texas Abstract Oxidative stress plays a pathogenic role in hypertension, particularly the one associated with diabetes and obesity. Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by […]
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Tempol Inhibits Pancreatic Cancer Cell Growth
Free Radical Biology and Medicine, Volume 49, Supplement, 2010, Pages S58 Du J¹, Olney K¹, Schrock H¹, Moser J¹, Wagner B¹, Sibenaller Z¹, Buettner G¹, Cullen J¹ ¹Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa ABSTRACT NOT AVAILABLE ONLINE – See full ARTICLE
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Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers*
Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1507-11. Fujii N1, Brunt VE1, Minson CT1 1Department of Human Physiology, The University of Oregon, Eugene, Oregon. Abstract We recently found that young cigarette smokers display cutaneous vascular dysfunction relative to non-smokers, which is partially due to reduced nitric oxide (NO) synthase (NOS)-dependent vasodilation. In this study, […]
Antioxidant, Cardiovascular, Dermatological, Hypothermia, Ischemia, Oxidative Stress
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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294 Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]
Antioxidant, Brain Trauma, Immune, Inflammation, Mitochondria, Neurological, Oxidative Stress, Parkinson's Disease
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Tempol produced regression of Crohn’s Disease
Oxidative stress plays a significant role in the pathogenesis of inflammatory bowel disease. Endogenous antioxidants such as superoxide dismutase (SOD), glutathione, and catalase are normally able to counteract oxidative stress in the intestinal mucosa. However, inflammation increases the demand for these important antioxidants and results in an imbalance between pro-oxidants and antioxidants, with subsequent mucosal […]
Christopher S. Wilcox, M.D., Ph.D. - Pharmacol Ther. May 2010; 126(2): 119–145.
Tempol is a redox cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in animal models of oxidative stress. Tempol has been shown to preserve mitochondria against oxidative damage and improve tissue oxygenation.
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