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Category Archives: Anti-aging

SOD2 and GSH are critical for the cellular antioxidant defense in neurodegenerative diseases and acute brain disorders.

Neurochem Int. 2015 Jan 6. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Ruszkiewicz J1, Albrecht J2. 1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. 2Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. Abstract Oxidative and nitrosative stress […]

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MnSOD, ROS, mitochondria, oxidative stress diseases and aging, superoxide theory

J Clin Biochem Nutr. 2015 Jan;56(1):1-7. A mitochondrial superoxide theory for oxidative stress diseases and aging. Indo HP1, Yen HC2, Nakanishi I3, Matsumoto K3, Tamura M4, Nagano Y4, Matsui H4, Gusev O5, Cornette R6, Okuda T6, Minamiyama Y7, Ichikawa H8, Suenaga S9, Oki M10, Sato T9, Ozawa T11, Clair DK12, Majima HJ13.   1Department of […]

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Tempol may protect tissue around the base of the cornea.

J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]

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Involvement of peroxynitrite free radicals in retinal neurotoxicity.

Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]

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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.

Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]

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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.

Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]

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TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.

Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]

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The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.

Free Radic Biol Med. 2014 Dec;77:168-82. The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke. Dohare P1, Hyzinski-García MC1, Vipani A1, Bowens NH1, Nalwalk JW1, Feustel PJ1, Keller RW Jr1, Jourd’heuil D2, Mongin AA3. 1Center for Neuropharmacology and Neuroscience, Albany […]

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Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.

J Biol Chem. 2015 Mar 17. Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1. Bhattacharyya S1, Feferman L2, Tobacman JK3. 1University of Illinois at Chicago, United States 2University of Illinois at Chicago and Jesse Brown VA Medical Center, United States. 3University of Illinois at Chicago and Jesse Brown […]

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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction.

J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]

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