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Category Archives: Autoimmune

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Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.

Acta Physiol Scand Suppl. 1980;492:59-65.  Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.  Emerit I, Michelson AM.   Abstract Increased chromosome breakage is observed in lymphocyte cultures from patients with so-called autoimmune diseases also in the animal model, the NZB mouse. A clastogenic agent was detected in the serum of […]

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Nitroxide stable radical suppresses autoimmune uveitis in rats.

Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]

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Tempol produced regression of Crohn’s Disease

Oxidative stress plays a significant role in the pathogenesis of inflammatory bowel disease. Endogenous antioxidants such as superoxide dismutase (SOD), glutathione, and catalase are normally able to counteract oxidative stress in the intestinal mucosa. However, inflammation increases the demand for these important antioxidants and results in an imbalance between pro-oxidants and antioxidants, with subsequent mucosal […]

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