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Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?

Journal of Nutrition and Metabolism {focus_keyword} Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer? Journal of Nutrition and Metabolism

 

 

 

 

Nutr Metab (Lond). 2010 Jan 27;7:7.

Cancer as a metabolic disease.

Seyfried TN1, Shelton LM.

1Biology Department, Boston College, Chestnut Hill, MA 02467, USA.

Abstract

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

 

{focus_keyword} Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer? Cancer is Metabolic 1B

Figure 1 – Activation of the retrograde response (RTG) response in yeast cells. The circled Ps are phosphate groups. SLP, (substrate level phosphorylation). See text for description of the RTG response.

{focus_keyword} Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer? Cancer is MEtabolic 2B

Figure 2 – Linking the hallmarks of cancer to impaired energy metabolism. See text for discussion. SLP and OxPhos represent substrate level phosphorylation and oxidative phosphorylation, respectively. The progressive damage to mitochondria during carcinogenesis is illustrated with a change in shape.

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