Tempol could resolve stress in the pathogenesis of organophosphate pesticides (Op) toxicity
Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S37-40. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Surajudeen YA1, Sheu RK1, Ayokulehin KM2, Olatunbosun AG1. 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 2Institute for Advanced Medical Research and Training, College of Medicine, University of […]
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Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol
Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]
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Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?
Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]
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Tempol suppresses EMF induced epigenetic changes
Mutat Res. 2012 Aug 30;747(1):138-41. Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration. Miyakoshi Y1, Kajihara C, Shimizu H, Yanagisawa H. 1Department of Public Health and Environmental Medicine, the Jikei University School of Medicine, Tokyo, Japan. Abstract A number of epidemiological studies have suggested that […]
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Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
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Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells
Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]
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Tempol disrupts CtBP1 binding to Brca1
Oncogene. 2010 Dec 16;29(50):6603-8. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 Deng Y1, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. 1Department of Dermatology, University of Colorado, Denver, Aurora, CO 80045, USA. Abstract C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic […]
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Tempol inhibits mitochondrial superoxide: a novel specific anticancer treatment with reduced cytotoxic side effects
Antioxid Redox Signal. 2013 Aug 1;19(4):344-9. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR1, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor’ev IA, Dikalov SI. 1Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) […]
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Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.
PLoS One. 2014 Oct 1;9(10) Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Ahmed LA1, Shehata NI2, Abdelkader NF1, Khattab MM1. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Abstract BACKGROUND: Mitochondrial dysfunction […]
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SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
Mol Cancer Ther. 2012 Jan;11(1):87-97. SOD mimetics: a novel class of androgen receptor inhibitors that suppresses castration-resistant growth of prostate cancer. Thomas R1, Sharifi N. 1Department of Internal Medicine, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Abstract Advanced prostate cancer is the second leading cause of cancer-related deaths among […]
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