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Category Archives: Cancer

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Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.

Cancer Res. 2008 Mar 1;68(5):1601-8. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS1, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. 1Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA. Abstract Fanconi anemia (FA) is a […]

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Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.

Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA.   Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.  Summary Skin cancer is the […]

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TEMPOL for Cancer

TEMPOL for Cancer– Why Treat Fibrocystic Change? Jan 11, 2015 Peter H Proctor, PhD, MD TEMPOL is a small-molecule “SOD-mimetic”, effective in a variety of experimental cancer models, both in vivo and in vitro. Tracing back to the Warburg effect, its putative mechanism of action is destruction of reactive oxygen species (ROS). These drive the […]

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Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.

Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]

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The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.

Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]

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Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

Cancer Lett. 2014 Oct 28;353(2):248-57 Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol. Georgakilas AG1, Redon CE2, Ferguson NF3, Kryston TB3, Parekh P2, Dickey JS4, Nakamura AJ5, Mitchell JB6, Bonner WM2, Martin OA7. 1Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, […]

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Tempol protects human lymphocytes from genotoxicity induced by cisplatin.

Int J Clin Exp Med. 2014 Apr 15;7(4):982-8 Tempol protects human lymphocytes from genotoxicity induced by cisplatin. Khabour OF1, Alzoubi KH2, Mfady DS1, Alasseiri M1, Hasheesh TF1. 1Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology Irbid, Jordan. 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of […]

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TEMPOL-H for Fibrocystic Breast Disease– Case Report.

SFRBM (Society For Free Radical Biology and Medicine) Meeting, Nov. 20-24, 2013, San Antonio, TX Peter Proctor, Donna RollingProctor ABSTRACT Variably presenting with painful cysts and mastodynia, fibrocystic disease of breast (FD) affects 30-40% of women. FD complicates breast cancer diagnosis by requiring work-up of lumps to rule-out malignancy and by obscuring malignant lesions. Although […]

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A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.

Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]

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Therapeutic and Clinical Applications of Nitroxide Compounds

Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]

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