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Category Archives: Dermatological

A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.

Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]

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Therapeutic and Clinical Applications of Nitroxide Compounds

Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]

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Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection. [Article in Polish]

Postepy Hig Med Dosw (Online). 2011 Feb 2;65:46-54. [Article in Polish] Tabaczar S¹, Talar M, Gwoździński K. Abstract Nitroxides as stabile organic radicals were used initially as spin labels in spectroscopy of electron paramagnetic resonance (EPR) with respect to parameters such as pH of an intercellular environment, oxygenation of cells and tissues, fluidity of biological membranes, […]

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Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome.

Brain Dev. 2005 Jan;27(1):34-8. Hayashi M¹, Araki S, Kohyama J, Shioda K, Fukatsu R. Abstract Xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are caused by a genetic defect of nucleotide excision repair mechanisms, showing cutaneous hypersensitivity to sunlight and progressive neurological disturbances. The cause of neurological abnormalities has yet to be clarified and […]

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Oxidative stress in developmental brain disorders.

Neuropathology. 2009 Feb;29(1):1-8.  Hayashi M¹. ¹Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. Abstract Oxidative stress is one of the predisposing factors in adult neurological disorders. We have examined the involvement of oxidative stress in child-onset neurodegenerative disorders, and here we review the findings from our analysis. In cases of Cockayne syndrome, […]

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Possible protective effect by SOD on UV damage in xeroderma pigmentosum (XP)

  J Invest Dermatol. 1989 Oct;93(4):506-10. Reduced superoxide dismutase activity in xeroderma pigmentosum fibroblasts. Nishigori C¹, Miyachi Y, Imamura S, Takebe H. ¹Department of Dermatology, Faculty of Medicine, Kyoto University, Japan. Abstract This study was performed in order to assess the possible protective effect of superoxide dismutase (SOD) on ultraviolet (UV) damage in xeroderma pigmentosum […]

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Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers*

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1507-11. Fujii N1, Brunt VE1, Minson CT1 1Department of Human Physiology, The University of Oregon, Eugene, Oregon. Abstract We recently found that young cigarette smokers display cutaneous vascular dysfunction relative to non-smokers, which is partially due to reduced nitric oxide (NO) synthase (NOS)-dependent vasodilation. In this study, […]

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