Indian J Clin Biochem. 2010 Oct;25(4):388-92. Role of oxidative stress in various stages of psoriasis. Kadam DP1, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH. 1Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra India. Abstract Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous […]Take a Tour
Cell Signal. 2015 Mar;27(3):460-9. Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors. Rai P1, Singh T1, Lederman R1, Chawla A1, Kumar D1, Cheng K1, Valecha G1, Mathieson PW1, Saleem MA1, Malhotra A1, Singhal PC2. 1Department of Medicine, Feinstein Institute for Medical Research, North Shore LIJ Medical School, NY, USA; Department […]Take a Tour
J Mol Cell Cardiol. 2011 Nov;51(5):876-80. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. Bai YL1, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL. 1Department of Pharmacology the State-Province Key Laboratories of Biomedicine-Pharmaceutics of […]Take a Tour
Cancer Res. 2008 Mar 1;68(5):1601-8. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS1, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. 1Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA. Abstract Fanconi anemia (FA) is a […]Take a Tour
Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure. Summary Skin cancer is the […]Take a Tour
TEMPOL for Cancer– Why Treat Fibrocystic Change? Jan 11, 2015 Peter H Proctor, PhD, MD TEMPOL is a small-molecule “SOD-mimetic”, effective in a variety of experimental cancer models, both in vivo and in vitro. Tracing back to the Warburg effect, its putative mechanism of action is destruction of reactive oxygen species (ROS). These drive the […]Take a Tour
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]Take a Tour
The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]Take a Tour
Aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by Tempol and Apocynin.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]Take a Tour
Environ Mol Mutagen. 2014 Aug;55(7):566-72. Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and Tempol. Olivero OA1, Ongele MO, Braun HM, Marrogi A, Divi K, Mitchell JB, Poirier MC. 1Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Abstract The cytokinesis-block […]Take a Tour