Low Superoxide Dismutase and Catalase Activities and their Correlation with Malondialdehyde In Schizophrenic Patients
Indian J Clin Biochem. 2004 Jul;19(2):114-8.
Superoxide Dismutase and Catalase Activities and their Correlation with Malondialdehyde in Schizophrenic Patients.
Rukmini MS1, D’Souza B, D’Souza V.
- 1Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, 575 004 Mangalore, India.
Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide, hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired. Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development of novel therapeutic strategies, such as antioxidant supplementation.