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Category Archives: Mitochondria

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Tempol and caspase inhibition reduced the production of ROS in glaucoma.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA.   Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]

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Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model.

Toxicol Sci. 2012 Oct;129(2):411-20. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Solesio ME1, Saez-Atienzar S, Jordán J, Galindo MF. 1Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Abstract In the present study, the activation of autophagy and its interaction with the mitochondrial fission machinery was investigated in an experimental model […]

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Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme.

J Biol Chem. 2014 Oct 31;289(44):30690-701. Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme. Coelho FR1, Iqbal A1, Linares E1, Silva DF1, Lima FS1, Cuccovia IM1, Augusto O2. 1From the Departamento de Bioquímica, Instituto de Química, Universidade de São […]

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Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease.

Biochem Pharmacol. 2005 Nov 1;70(9):1371-81. Liang Q¹, Smith AD, Pan S, Tyurin VA, Kagan VE, Hastings TG, Schor NF. ¹Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA Abstract TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) is a stable nitroxyl antioxidant. Previous studies have suggested that TEMPOL is protective in acute disorders thought to involve reactive oxygen species (ROS), such as […]

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Tempol Moderately Extends Survival in a hSOD1G93A ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1G93A Forms

PLoS One. 2013; 8(2): e55868. Linares E¹, Seixas LV, dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O. ¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms […]

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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294    Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]

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