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Tag Archives: AMD

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Tempol may protect tissue around the base of the cornea.

J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]

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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.

Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]

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