Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells
Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]Take a Tour
Tempol diminishes cocaine-induced oxidative damage
Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]Take a Tour
Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]Take a Tour
Tempol ameliorates ROS and apnea-induced hypertension.
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2971-6. Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Troncoso Brindeiro CM1, da Silva AQ, Allahdadi KJ, Youngblood V, Kanagy NL. 1Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA. Abstract In clinical studies, sleep apnea is associated with hypertension, oxidative […]Take a Tour
Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.
Am J Respir Cell Mol Biol. 2012 Feb;46(2):139-48. Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Skelly JR1, Edge D, Shortt CM, Jones JF, Bradford A, O’Halloran KD. 1Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. Abstract Respiratory muscle dysfunction is implicated in the […]Take a Tour
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]Take a Tour
The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]Take a Tour
WR-1065 and Tempol protected MOLT-3 cells against specific types of AZT-induced DNA damage.
Environ Mol Mutagen. 2014 Aug;55(7):566-72. Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and Tempol. Olivero OA1, Ongele MO, Braun HM, Marrogi A, Divi K, Mitchell JB, Poirier MC. 1Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Abstract The cytokinesis-block […]Take a Tour
Involvement of peroxynitrite free radicals in retinal neurotoxicity.
Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]Take a Tour
Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]Take a Tour