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Tag Archives: endothelium

Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol

Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]

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Aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by Tempol and Apocynin.

J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]

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Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.

Redox Biol. 2014;3:88-99. Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall. Liu Z1, Gou Y2, Zhang H3, Zuo H1, Zhang H4, Liu Z5, Yao D6. 1Internal Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 2Department of Neurology, Wuhan No. 1 Hospital, #215 Zhongshan […]

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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.

Circulation. 2015 Jan 20;131(3):289-99. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Gibson CC1, Zhu W1, Davis CT1, Bowman-Kirigin JA1, Chan AC1, Ling J1, Walker AE1, Goitre L1, Delle Monache S1, Retta SF1, Shiu YT1, Grossmann AH1, Thomas KR1, Donato AJ1, Lesniewski LA1, Whitehead KJ1, Li DY2. 1From the Program in […]

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