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Tag Archives: hydrogen peroxide

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Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells

Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]

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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294    Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]

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