Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
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Benefits of losartan and tempol in renal inflammation by hypernatremia.
Free Radic Res. 2015 Apr;49(4):383-96. Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Della Penna SL1, Rosón MI, Toblli JE, Fernández BE. 1Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Argentina. Abstract The body regulates plasma sodium levels […]
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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Pharmacol Res. 2014 Mar;81:91-102. Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD). Impellizzeri D1, Esposito E1, Attley J2, Cuzzocrea S3. 1Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. 2Prismic Pharmaceuticals, Scottsdale, AZ, USA. 3Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno […]
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Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.
J Biol Chem. 2015 Mar 17. Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1. Bhattacharyya S1, Feferman L2, Tobacman JK3. 1University of Illinois at Chicago, United States 2University of Illinois at Chicago and Jesse Brown VA Medical Center, United States. 3University of Illinois at Chicago and Jesse Brown […]
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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Pharmacol Res. 2014 Mar;81:91-102. Impellizzeri D¹, Esposito E¹, Attley J², Cuzzocrea S³. ¹Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. ²Prismic Pharmaceuticals, Scottsdale, AZ, USA. ³Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy; Manchester Biomedical Research Centre, Manchester Royal […]
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Nitroxide stable radical suppresses autoimmune uveitis in rats.
Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]
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