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Tag Archives: ocular

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Tempol may protect tissue around the base of the cornea.

J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]

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Tempol and Vitamin C provide a potential novel treatment strategy for age-related macular degeneration.

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells. Lau LI1, Chiou SH, Liu CJ, Yen MY, Wei YH. 1Institute of Clinical Medicine, School ofMedicine, National Yang-Ming University, Taipei, Taiwan.   Abstract PURPOSE: Genetic variation in complement factor H […]

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Tempol and caspase inhibition reduced the production of ROS in glaucoma.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA.   Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]

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