TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
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Tempol could resolve stress in the pathogenesis of organophosphate pesticides (Op) toxicity
Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S37-40. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Surajudeen YA1, Sheu RK1, Ayokulehin KM2, Olatunbosun AG1. 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 2Institute for Advanced Medical Research and Training, College of Medicine, University of […]
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Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol
Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]
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Tempol diminishes cocaine-induced oxidative damage
Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]
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Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]
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The mitochondrion: a perpetrator of acquired hearing loss.
Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]
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Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.
Redox Biol. 2014;3:88-99. Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall. Liu Z1, Gou Y2, Zhang H3, Zuo H1, Zhang H4, Liu Z5, Yao D6. 1Internal Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 2Department of Neurology, Wuhan No. 1 Hospital, #215 Zhongshan […]
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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]
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TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.
Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]
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Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Hum Mol Genet. 2005 Jun 15;14(12):1699-708. Epub 2005 May 11. Erker L¹, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A. ¹Department of Pediatrics, UCSD School of Medicine, La Jolla, CA Abstract We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient […]
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