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Tag Archives: Retinal Degeneration/metabolism

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Tempol and Vitamin C provide a potential novel treatment strategy for age-related macular degeneration.

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells. Lau LI1, Chiou SH, Liu CJ, Yen MY, Wei YH. 1Institute of Clinical Medicine, School ofMedicine, National Yang-Ming University, Taipei, Taiwan.   Abstract PURPOSE: Genetic variation in complement factor H […]

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Tempol and caspase inhibition reduced the production of ROS in glaucoma.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA.   Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]

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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.

Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]

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TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.

Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]

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