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Tag Archives: ROS

Tempol could resolve stress in the pathogenesis of organophosphate pesticides (Op) toxicity

Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S37-40. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Surajudeen YA1, Sheu RK1, Ayokulehin KM2, Olatunbosun AG1. 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 2Institute for Advanced Medical Research and Training, College of Medicine, University of […]

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Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol

Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]

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Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?

        Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]

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Tempol diminishes cocaine-induced oxidative damage

Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]

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The mitochondrion: a perpetrator of acquired hearing loss.

Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]

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MnSOD, ROS, mitochondria, oxidative stress diseases and aging, superoxide theory

J Clin Biochem Nutr. 2015 Jan;56(1):1-7. A mitochondrial superoxide theory for oxidative stress diseases and aging. Indo HP1, Yen HC2, Nakanishi I3, Matsumoto K3, Tamura M4, Nagano Y4, Matsui H4, Gusev O5, Cornette R6, Okuda T6, Minamiyama Y7, Ichikawa H8, Suenaga S9, Oki M10, Sato T9, Ozawa T11, Clair DK12, Majima HJ13.   1Department of […]

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Tempol may protect tissue around the base of the cornea.

J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]

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Tempol and caspase inhibition reduced the production of ROS in glaucoma.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA.   Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]

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Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model.

Toxicol Sci. 2012 Oct;129(2):411-20. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Solesio ME1, Saez-Atienzar S, Jordán J, Galindo MF. 1Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Abstract In the present study, the activation of autophagy and its interaction with the mitochondrial fission machinery was investigated in an experimental model […]

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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294    Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]

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