TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
Take a Tour
Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
Take a Tour
TEMPOL had a significant positive impact on body mass, atherosclerosis, hyperlipidaemia and inflammation
Atherosclerosis. 2015 May;240(1):234-41. The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice. Kim CH1, Mitchell JB2, Bursill CA3, Sowers AL4, Thetford A5, Cook JA6, van Reyk DM7, Davies MJ8. 1Free Radical Group, Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia; Faculty of Medicine, […]
Take a Tour
Tempol improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease
Synapse. 2015 Mar;69(3):128-38. 4-hydroxy tempo (Tempol) improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease. Sandhir R1, Mahajan N, Mehrotra A, Aggarwal A, Sunkaria A. 1Department of Biochemistry, Panjab University, Chandigarh, 160014, Punjab, India. Abstract Mitochondrial dysfunctions have been implicated in the progression of Huntington’s disease (HD). To date, several free radical scavengers […]
Take a Tour
Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
Take a Tour
Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells
Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]
Take a Tour
Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
Take a Tour
Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Cancer Res. 2008 Mar 1;68(5):1601-8. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS1, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. 1Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA. Abstract Fanconi anemia (FA) is a […]
Take a Tour
Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.
Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure. Summary Skin cancer is the […]
Take a Tour
Benefits of losartan and tempol in renal inflammation by hypernatremia.
Free Radic Res. 2015 Apr;49(4):383-96. Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Della Penna SL1, Rosón MI, Toblli JE, Fernández BE. 1Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Argentina. Abstract The body regulates plasma sodium levels […]
Take a Tour
