Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
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Mitochondrial antioxidants Tempol and EUK-134 effect in neurodegenerative diseases without the need of liposomes.
Eur J Pharmacol. 2002 Jul 5;447(2-3):155-61. Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases? Dessolin J1, Schuler M, Quinart A, De Giorgi F, Ghosez L, Ichas F. 1European Institute of Chemistry and Biology and INSERM E.9929, Université Victor Segalen-Bordeaux 2, 33076 Bordeaux cedex, France. Abstract Mitochondria are the major […]
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Tempol, NAC and pioglitazone all restored cerebrovascular reactivity in aged Alzheimer’s disease transgenic mice.
J Neurosci. 2008 Sep 10;28(37):9287-96. Complete rescue of cerebrovascular function in aged Alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. Nicolakakis N1, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. 1Laboratory of Cerebrovascular Research, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. Abstract […]
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SOD2 and GSH are critical for the cellular antioxidant defense in neurodegenerative diseases and acute brain disorders.
Neurochem Int. 2015 Jan 6. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Ruszkiewicz J1, Albrecht J2. 1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. 2Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. Abstract Oxidative and nitrosative stress […]
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Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model.
Toxicol Sci. 2012 Oct;129(2):411-20. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Solesio ME1, Saez-Atienzar S, Jordán J, Galindo MF. 1Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Abstract In the present study, the activation of autophagy and its interaction with the mitochondrial fission machinery was investigated in an experimental model […]
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Therapeutic and Clinical Applications of Nitroxide Compounds
Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]
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Oxidative stress in developmental brain disorders.
Neuropathology. 2009 Feb;29(1):1-8. Hayashi M¹. ¹Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. Abstract Oxidative stress is one of the predisposing factors in adult neurological disorders. We have examined the involvement of oxidative stress in child-onset neurodegenerative disorders, and here we review the findings from our analysis. In cases of Cockayne syndrome, […]
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