Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.
Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure. Summary Skin cancer is the […]Take a Tour
Tempol restores erectile dysfunction in diabetic models
J Urol. 2009 Nov;182(5):2518-25. Restoring erectile function by antioxidant therapy in diabetic rats. Hirata H1, Kawamoto K, Kikuno N, Kawakami T, Kawakami K, Saini S, Yamamura S, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, California 94121, USA. Abstract PURPOSE: Diabetes mediates an increase in reactive oxygen […]Take a Tour
Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]Take a Tour
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening.
J Biol Chem. 2003 Feb 28;278(9):6824-30. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. Serra V1, von Zglinicki T, Lorenz M, Saretzki G. 1Institute of Pathology and Research Laboratory Cardiology, Charité Hospital, D-10098 Berlin, Germany. Abstract There is good evidence that telomere shortening acts as a biological clock in […]Take a Tour
Aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by Tempol and Apocynin.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]Take a Tour
The mitochondrion: a perpetrator of acquired hearing loss.
Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]Take a Tour
Creatine and tempol attenuate noise-induced hearing loss.
Brain Res. 2007 May 7;1148:83-9. Creatine and tempol attenuate noise-induced hearing loss. Minami SB1, Yamashita D, Ogawa K, Schacht J, Miller JM. 1Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA. Abstract To define the role of free radical formation and potential energy depletion in noise induced hearing […]Take a Tour
Tempol, NAC and pioglitazone all restored cerebrovascular reactivity in aged Alzheimer’s disease transgenic mice.
J Neurosci. 2008 Sep 10;28(37):9287-96. Complete rescue of cerebrovascular function in aged Alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. Nicolakakis N1, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. 1Laboratory of Cerebrovascular Research, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. Abstract […]Take a Tour
SOD and mitochondria quality control in ALS.
Brain Res. 2015 May 14 Exploring new pathways of neurodegeneration in ALS: The role of mitochondria quality control. Palomo GM1, Manfredi G2. 1Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United States. 2Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United […]Take a Tour
Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.
Redox Biol. 2014;3:88-99. Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall. Liu Z1, Gou Y2, Zhang H3, Zuo H1, Zhang H4, Liu Z5, Yao D6. 1Internal Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 2Department of Neurology, Wuhan No. 1 Hospital, #215 Zhongshan […]Take a Tour