Nitroxide stable radical suppresses autoimmune uveitis in rats.
Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]Take a Tour
Tempol Moderately Extends Survival in a hSOD1G93A ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1G93A Forms
PLoS One. 2013; 8(2): e55868. Linares E¹, Seixas LV, dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O. ¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms […]Take a Tour
Tempol reduces oxidative stress, improves insulin sensitivity.
Diabetes. 2005 Jul;54(7):2219-26. Banday AA¹, Marwaha A, Tallam LS, Lokhandwala MF. ¹Heart and Kidney Institute, University of Houston, Houston, Texas Abstract Oxidative stress plays a pathogenic role in hypertension, particularly the one associated with diabetes and obesity. Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by […]Take a Tour
Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers*
Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1507-11. Fujii N1, Brunt VE1, Minson CT1 1Department of Human Physiology, The University of Oregon, Eugene, Oregon. Abstract We recently found that young cigarette smokers display cutaneous vascular dysfunction relative to non-smokers, which is partially due to reduced nitric oxide (NO) synthase (NOS)-dependent vasodilation. In this study, […]Take a Tour
Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294 Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]Take a Tour
Tempol produced regression of Crohn’s Disease
Oxidative stress plays a significant role in the pathogenesis of inflammatory bowel disease. Endogenous antioxidants such as superoxide dismutase (SOD), glutathione, and catalase are normally able to counteract oxidative stress in the intestinal mucosa. However, inflammation increases the demand for these important antioxidants and results in an imbalance between pro-oxidants and antioxidants, with subsequent mucosal […]Take a Tour