Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
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Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]
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Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
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SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
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Tempol for SOD and catalase deficiency in psoriasis
Indian J Clin Biochem. 2010 Oct;25(4):388-92. Role of oxidative stress in various stages of psoriasis. Kadam DP1, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH. 1Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra India. Abstract Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous […]
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Antioxidant defense capacity in scleroderma patients.
Clin Chem Lab Med. 2008;46(6):836-41. Antioxidant defense capacity in scleroderma patients. Sfrent-Cornateanu R1, Mihai C, Stoian I, Lixandru D, Bara C, Moldoveanu E. 1Department of Physiopathology and Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania. Abstract BACKGROUND: Oxidative stress is associated with scleroderma (systemic sclerosis) and is supposed to favor disease progression by […]
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Orgotein in the treatment of plastic induration of the penis (Peyronie’s disease).
Int Urol Nephrol. 1993;25(2):169-72. Orgotein in the treatment of plastic induration of the penis (Peyronie’s disease). Primus G1. 1Department of Urology, LKH, Graz, Austria. Abstract Eighteen patients with Peyronie’s disease have been treated with the anti-inflammatory metalloprotein Orgotein, which exhibits a pronounced superoxide dismutase activity. Only patients with severe symptoms were selected. The drug was […]
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Intrathecal orgotein.
Int J Clin Pharmacol Res. 1985;5(1):59-62. Intrathecal orgotein. Lund-Olesen K. Abstract During the period 1971-78, 133 intrathecal injections of orgotein or superoxide dismutase have been given, mostly to patients with multiple sclerosis. Evaluation of the effect was deficient but the impression was that of improvement and 45% of the 58 patients with multiple sclerosis requested […]
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Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma.
J Invest Dermatol. 2004 Mar;122(3):594-601. Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma. Nagai M1, Hasegawa M, Takehara K, Sato S. 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Abstract Abnormal production of reactive oxygen species (ROS) induces tissue damage and superoxide dismutase (SOD) that converts superoxide radicals […]
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Topical application of superoxide dismutase cream.
Drugs Exp Clin Res. 1991;17(2):127-31. Topical application of superoxide dismutase cream. Mizushima Y1, Hoshi K, Yanagawa A, Takano K. 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan. Abstract A superoxide dismutase (SOD) cream containing 0.6 mg/ml of bovine SOD was prepared. It was applied locally onto the skin and mucosal lesions […]
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