Tempol suppresses EMF induced epigenetic changes
Mutat Res. 2012 Aug 30;747(1):138-41. Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration. Miyakoshi Y1, Kajihara C, Shimizu H, Yanagisawa H. 1Department of Public Health and Environmental Medicine, the Jikei University School of Medicine, Tokyo, Japan. Abstract A number of epidemiological studies have suggested that […]Take a Tour
Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]Take a Tour
Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]Take a Tour
Mitochondrial antioxidants Tempol and EUK-134 effect in neurodegenerative diseases without the need of liposomes.
Eur J Pharmacol. 2002 Jul 5;447(2-3):155-61. Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases? Dessolin J1, Schuler M, Quinart A, De Giorgi F, Ghosez L, Ichas F. 1European Institute of Chemistry and Biology and INSERM E.9929, Université Victor Segalen-Bordeaux 2, 33076 Bordeaux cedex, France. Abstract Mitochondria are the major […]Take a Tour
Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]Take a Tour
Tempol diminishes cocaine-induced oxidative damage
Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]Take a Tour
Polymorphisms in superoxide dismutase genes in autism spectrum disorder.
Autism Res. 2014 Feb;7(1):138-44. Rare single nucleotide polymorphisms in the regulatory regions of the superoxide dismutase genes in autism spectrum disorder. Kovač J1, Macedoni Lukšič M, Trebušak Podkrajšek K, Klančar G, Battelino T. 1Department of Endocrinology, Diabetes and Metabolic Diseases, UMC Ljubljana, University Children’s Hospital, Ljubljana, Slovenia. Abstract Oxidative stress is suspected to be one […]Take a Tour
Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]Take a Tour
Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.
Am J Respir Cell Mol Biol. 2012 Feb;46(2):139-48. Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Skelly JR1, Edge D, Shortt CM, Jones JF, Bradford A, O’Halloran KD. 1Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. Abstract Respiratory muscle dysfunction is implicated in the […]Take a Tour
Oxidative stress in autism.
Pathophysiology. 2006 Aug;13(3):171-81. Oxidative stress in autism. Chauhan A1, Chauhan V. 1NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. Abstract Autism is a severe developmental disorder with poorly understood etiology. Oxidative stress in autism has been studied at the membrane level and also by measuring products […]Take a Tour