Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation.
Biol Trace Elem Res. 2011 Oct;143(1):58-65. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Meguid NA1, Dardir AA, Abdel-Raouf ER, Hashish A. 1Department of Research on Children with Special Needs, National Research Center, Tahrir St, Cairo, Egypt. Abstract Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and […]
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Tempol, NAC and pioglitazone all restored cerebrovascular reactivity in aged Alzheimer’s disease transgenic mice.
J Neurosci. 2008 Sep 10;28(37):9287-96. Complete rescue of cerebrovascular function in aged Alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. Nicolakakis N1, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. 1Laboratory of Cerebrovascular Research, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada. Abstract […]
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SOD and mitochondria quality control in ALS.
Brain Res. 2015 May 14 Exploring new pathways of neurodegeneration in ALS: The role of mitochondria quality control. Palomo GM1, Manfredi G2. 1Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United States. 2Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United […]
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SOD2 and GSH are critical for the cellular antioxidant defense in neurodegenerative diseases and acute brain disorders.
Neurochem Int. 2015 Jan 6. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Ruszkiewicz J1, Albrecht J2. 1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. 2Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. Abstract Oxidative and nitrosative stress […]
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Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]
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MnSOD, ROS, mitochondria, oxidative stress diseases and aging, superoxide theory
J Clin Biochem Nutr. 2015 Jan;56(1):1-7. A mitochondrial superoxide theory for oxidative stress diseases and aging. Indo HP1, Yen HC2, Nakanishi I3, Matsumoto K3, Tamura M4, Nagano Y4, Matsui H4, Gusev O5, Cornette R6, Okuda T6, Minamiyama Y7, Ichikawa H8, Suenaga S9, Oki M10, Sato T9, Ozawa T11, Clair DK12, Majima HJ13. 1Department of […]
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Involvement of peroxynitrite free radicals in retinal neurotoxicity.
Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]
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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.
Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]
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Tempol and caspase inhibition reduced the production of ROS in glaucoma.
Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA. Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]
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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]
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