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Category Archives: Brain Trauma

Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease.

Biochem Pharmacol. 2005 Nov 1;70(9):1371-81. Liang Q¹, Smith AD, Pan S, Tyurin VA, Kagan VE, Hastings TG, Schor NF. ¹Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA Abstract TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) is a stable nitroxyl antioxidant. Previous studies have suggested that TEMPOL is protective in acute disorders thought to involve reactive oxygen species (ROS), such as […]

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Nitroxide stable radical suppresses autoimmune uveitis in rats.

Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]

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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294    Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]

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