Tempol could resolve stress in the pathogenesis of organophosphate pesticides (Op) toxicity
Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S37-40. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Surajudeen YA1, Sheu RK1, Ayokulehin KM2, Olatunbosun AG1. 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. 2Institute for Advanced Medical Research and Training, College of Medicine, University of […]
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Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol
Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]
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TEMPOL had a significant positive impact on body mass, atherosclerosis, hyperlipidaemia and inflammation
Atherosclerosis. 2015 May;240(1):234-41. The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice. Kim CH1, Mitchell JB2, Bursill CA3, Sowers AL4, Thetford A5, Cook JA6, van Reyk DM7, Davies MJ8. 1Free Radical Group, Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia; Faculty of Medicine, […]
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Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
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Aging and senescence induced by telomere shortening, cause endothelial dysfunction that can be restored by Tempol and Apocynin.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]
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Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.
Redox Biol. 2014;3:88-99. Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall. Liu Z1, Gou Y2, Zhang H3, Zuo H1, Zhang H4, Liu Z5, Yao D6. 1Internal Medicine of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 2Department of Neurology, Wuhan No. 1 Hospital, #215 Zhongshan […]
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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Circulation. 2015 Jan 20;131(3):289-99. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Gibson CC1, Zhu W1, Davis CT1, Bowman-Kirigin JA1, Chan AC1, Ling J1, Walker AE1, Goitre L1, Delle Monache S1, Retta SF1, Shiu YT1, Grossmann AH1, Thomas KR1, Donato AJ1, Lesniewski LA1, Whitehead KJ1, Li DY2. 1From the Program in […]
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Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress.
Hypertension. 2015 Mar 2. Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress. Banday AA1, Lokhandwala MF2. 1From the Heart and Kidney Institute, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX. 2From the Heart and Kidney Institute, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of […]
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Antihypertensive effect of mitochondria-targeted proxyl nitroxides.
Redox Biol. 2015;4:355-62. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Dikalova AE1, Kirilyuk IA2, Dikalov SI3. 1Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. 2Novosibirsk Institute of Organic Chemistry, Lavrentieva 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia. 3Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. […]
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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]
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