TEMPOL had a significant positive impact on body mass, atherosclerosis, hyperlipidaemia and inflammation
Atherosclerosis. 2015 May;240(1):234-41. The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice. Kim CH1, Mitchell JB2, Bursill CA3, Sowers AL4, Thetford A5, Cook JA6, van Reyk DM7, Davies MJ8. 1Free Radical Group, Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia; Faculty of Medicine, […]
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Tempol restores erectile dysfunction in diabetic models
J Urol. 2009 Nov;182(5):2518-25. Restoring erectile function by antioxidant therapy in diabetic rats. Hirata H1, Kawamoto K, Kikuno N, Kawakami T, Kawakami K, Saini S, Yamamura S, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, California 94121, USA. Abstract PURPOSE: Diabetes mediates an increase in reactive oxygen […]
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Tempol restores erectile function in diabetes-induced impotence.
Int J Impot Res. 2009 Nov-Dec;21(6):348-55. Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. Kawakami T1, Urakami S, Hirata H, Tanaka Y, Nakajima K, Enokida H, Shiina H, Ogishima T, Tokizane T, Kawamoto K, Miura K, Ishii N, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs […]
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Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]
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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.
Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]
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Tempol mitigates C-reactive protein induced retinal damage.
Invest Ophthalmol Vis Sci. 2008 May;49(5):2053-60. C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Nagaoka T1, Kuo L, Ren Y, Yoshida A, Hein TW. 1Department of Ophthalmology, Scott & White Eye Institute, Temple, TX 76504, USA. Abstract PURPOSE: Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated […]
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Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.
J Biol Chem. 2015 Mar 17. Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1. Bhattacharyya S1, Feferman L2, Tobacman JK3. 1University of Illinois at Chicago, United States 2University of Illinois at Chicago and Jesse Brown VA Medical Center, United States. 3University of Illinois at Chicago and Jesse Brown […]
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Tempol reduces oxidative stress, improves insulin sensitivity.
Diabetes. 2005 Jul;54(7):2219-26. Banday AA¹, Marwaha A, Tallam LS, Lokhandwala MF. ¹Heart and Kidney Institute, University of Houston, Houston, Texas Abstract Oxidative stress plays a pathogenic role in hypertension, particularly the one associated with diabetes and obesity. Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by […]
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