TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
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Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
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Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?
Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]
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Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
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Tempol disrupts CtBP1 binding to Brca1
Oncogene. 2010 Dec 16;29(50):6603-8. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 Deng Y1, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. 1Department of Dermatology, University of Colorado, Denver, Aurora, CO 80045, USA. Abstract C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic […]
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Tempol inhibits mitochondrial superoxide: a novel specific anticancer treatment with reduced cytotoxic side effects
Antioxid Redox Signal. 2013 Aug 1;19(4):344-9. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR1, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor’ev IA, Dikalov SI. 1Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) […]
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SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer
Mol Cancer Ther. 2012 Jan;11(1):87-97. SOD mimetics: a novel class of androgen receptor inhibitors that suppresses castration-resistant growth of prostate cancer. Thomas R1, Sharifi N. 1Department of Internal Medicine, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Abstract Advanced prostate cancer is the second leading cause of cancer-related deaths among […]
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Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]
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Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
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SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
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