TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
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TEMPOL had a significant positive impact on body mass, atherosclerosis, hyperlipidaemia and inflammation
Atherosclerosis. 2015 May;240(1):234-41. The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice. Kim CH1, Mitchell JB2, Bursill CA3, Sowers AL4, Thetford A5, Cook JA6, van Reyk DM7, Davies MJ8. 1Free Radical Group, Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia; Faculty of Medicine, […]
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Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]
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Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
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SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
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Tempol for SOD and catalase deficiency in psoriasis
Indian J Clin Biochem. 2010 Oct;25(4):388-92. Role of oxidative stress in various stages of psoriasis. Kadam DP1, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH. 1Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra India. Abstract Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous […]
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HIV Tat protein was prevented by antioxidant Tempol.
J Mol Cell Cardiol. 2011 Nov;51(5):876-80. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. Bai YL1, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL. 1Department of Pharmacology the State-Province Key Laboratories of Biomedicine-Pharmaceutics of […]
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Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]
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Benefits of losartan and tempol in renal inflammation by hypernatremia.
Free Radic Res. 2015 Apr;49(4):383-96. Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Della Penna SL1, Rosón MI, Toblli JE, Fernández BE. 1Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Argentina. Abstract The body regulates plasma sodium levels […]
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Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.
Cancer Lett. 2014 Oct 28;353(2):248-57 Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol. Georgakilas AG1, Redon CE2, Ferguson NF3, Kryston TB3, Parekh P2, Dickey JS4, Nakamura AJ5, Mitchell JB6, Bonner WM2, Martin OA7. 1Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, […]
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