Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Circulation. 2015 Jan 20;131(3):289-99. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Gibson CC1, Zhu W1, Davis CT1, Bowman-Kirigin JA1, Chan AC1, Ling J1, Walker AE1, Goitre L1, Delle Monache S1, Retta SF1, Shiu YT1, Grossmann AH1, Thomas KR1, Donato AJ1, Lesniewski LA1, Whitehead KJ1, Li DY2. 1From the Program in […]
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Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.
J Biol Chem. 2015 Mar 17. Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1. Bhattacharyya S1, Feferman L2, Tobacman JK3. 1University of Illinois at Chicago, United States 2University of Illinois at Chicago and Jesse Brown VA Medical Center, United States. 3University of Illinois at Chicago and Jesse Brown […]
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Antihypertensive effect of mitochondria-targeted proxyl nitroxides.
Redox Biol. 2015;4:355-62. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Dikalova AE1, Kirilyuk IA2, Dikalov SI3. 1Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. 2Novosibirsk Institute of Organic Chemistry, Lavrentieva 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia. 3Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. […]
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Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction.
J Gerontol A Biol Sci Med Sci. 2015 Mar 3. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. Bhayadia R1, Schmidt BM2, Melk A1, Hömme M1. 1Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Children’s Hospital, Hannover Medical School, Hannover D-30625, Germany. REBIRTH Excellence Cluster, Hannover Medical School, Hannover D-30625, Germany. 2Department of Nephrology, Hannover Medical School, […]
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Tempol protects blood proteins and lipids against peroxynitrite-mediated oxidative damage.
Exp Biol Med (Maywood). 2015 Jan;240(1):109-12. Tempol protects blood proteins and lipids against peroxynitrite-mediated oxidative damage. Mustafa AG1, Bani-Ahmad MA2, Jaradat AQ2, Allouh MZ3. 1Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. 2Department of Medical Laboratories, Faculty of Allied Medical Sciences, Jordan University of Science and Technology, Irbid […]
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Intrathecal orgotein.
Int J Clin Pharmacol Res. 1985;5(1):59-62. Intrathecal orgotein. Lund-Olesen K. Abstract During the period 1971-78, 133 intrathecal injections of orgotein or superoxide dismutase have been given, mostly to patients with multiple sclerosis. Evaluation of the effect was deficient but the impression was that of improvement and 45% of the 58 patients with multiple sclerosis requested […]
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A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.
Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]
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Therapeutic and Clinical Applications of Nitroxide Compounds
Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]
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Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection. [Article in Polish]
Postepy Hig Med Dosw (Online). 2011 Feb 2;65:46-54. [Article in Polish] Tabaczar S¹, Talar M, Gwoździński K. Abstract Nitroxides as stabile organic radicals were used initially as spin labels in spectroscopy of electron paramagnetic resonance (EPR) with respect to parameters such as pH of an intercellular environment, oxygenation of cells and tissues, fluidity of biological membranes, […]
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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Pharmacol Res. 2014 Mar;81:91-102. Impellizzeri D¹, Esposito E¹, Attley J², Cuzzocrea S³. ¹Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. ²Prismic Pharmaceuticals, Scottsdale, AZ, USA. ³Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy; Manchester Biomedical Research Centre, Manchester Royal […]
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