TEMPOL produced inhibition of MN formation and reduction in apoptotic and necrotic cells from mercury and lead toxicity.
Current Science (00113891) . 1/25/2013, Vol. 104 Issue 2, p224-228. Modification of cyto- and genotoxicity of mercury and lead by antioxidant on human lymphocytes in vitro. Roy, Arnab1; Kumar Dey, Subrata1; Saha, Chabita1 1School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Saltlake, Kolkata 700 099, India Abstract Mercury (30 μM) […]
Take a Tour
Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
Take a Tour
Endothelial dysfunction caused by Agent Orange induced ROS was restored by Tempol
Cardiovasc Toxicol. 2008 Dec;8(4):181-93. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Kopf PG1, Huwe JK, Walker MK. 1College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 2502 Marble NE, Albuquerque, NM 87131, USA. Abstract The mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the incidence of […]
Take a Tour
Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?
Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]
Take a Tour
Tempol improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease
Synapse. 2015 Mar;69(3):128-38. 4-hydroxy tempo (Tempol) improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease. Sandhir R1, Mahajan N, Mehrotra A, Aggarwal A, Sunkaria A. 1Department of Biochemistry, Panjab University, Chandigarh, 160014, Punjab, India. Abstract Mitochondrial dysfunctions have been implicated in the progression of Huntington’s disease (HD). To date, several free radical scavengers […]
Take a Tour
Tempol mitigates oxidative stress-induced cardiotoxicity in chemotherapeutics
PLoS One. 2013 Aug 5;8(8) Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. Dickey JS1, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner […]
Take a Tour
Tempol disrupts CtBP1 binding to Brca1
Oncogene. 2010 Dec 16;29(50):6603-8. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 Deng Y1, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. 1Department of Dermatology, University of Colorado, Denver, Aurora, CO 80045, USA. Abstract C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic […]
Take a Tour
Tempol inhibits mitochondrial superoxide: a novel specific anticancer treatment with reduced cytotoxic side effects
Antioxid Redox Signal. 2013 Aug 1;19(4):344-9. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR1, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor’ev IA, Dikalov SI. 1Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) […]
Take a Tour
Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.
PLoS One. 2014 Oct 1;9(10) Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Ahmed LA1, Shehata NI2, Abdelkader NF1, Khattab MM1. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Abstract BACKGROUND: Mitochondrial dysfunction […]
Take a Tour
SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
Take a Tour
