Tempol may protect tissue around the base of the cornea.
J Glaucoma. 1994 Summer;3(2):123-31. Studies of H2O2-Induced Effects on Cultured Bovine Trabecular Meshwork Cells. Padgaonkar V1, Giblin FJ, Leverenz V, Lin LR, Reddy VN. 1Eye Research Institute of Oakland University, Rochester, Michigan, U.S.A. Abstract The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. […]
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Involvement of peroxynitrite free radicals in retinal neurotoxicity.
Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]
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Antioxidant therapy with OT-674 (Tempol-H) may serve a protective role in AMD.
Photochem Photobiol. 2008 Jan-Feb;84(1):75-80. OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore. Zhou J1, Jang YP, Chang S, Sparrow JR. 1Department of Ophthalmology, Columbia University, New York, NY, USA. Abstract The pathological processes involved in age-related macular degeneration (AMD) include retinal pigment epithelial (RPE) cell degeneration; oxidative mechanisms likely contribute to the demise […]
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Tempol mitigates C-reactive protein induced retinal damage.
Invest Ophthalmol Vis Sci. 2008 May;49(5):2053-60. C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Nagaoka T1, Kuo L, Ren Y, Yoshida A, Hein TW. 1Department of Ophthalmology, Scott & White Eye Institute, Temple, TX 76504, USA. Abstract PURPOSE: Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated […]
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Tempol and Vitamin C provide a potential novel treatment strategy for age-related macular degeneration.
Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells. Lau LI1, Chiou SH, Liu CJ, Yen MY, Wei YH. 1Institute of Clinical Medicine, School ofMedicine, National Yang-Ming University, Taipei, Taiwan. Abstract PURPOSE: Genetic variation in complement factor H […]
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Tempol and caspase inhibition reduced the production of ROS in glaucoma.
Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4049-59. Caspase-independent component of retinal ganglion cell death, in vitro. Tezel G1, Yang X. 1Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA. Abstract PURPOSE: Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the […]
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Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]
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TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.
Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]
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