Fluoroquinolone antibiotics quenched by Tempol
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2. 1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]
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The mitochondrion: a perpetrator of acquired hearing loss.
Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]
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A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss.
Mech Ageing Dev. 2013 Jul-Aug;134(7-8):298-306. A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss. Nolan LS1, Cadge BA, Gomez-Dorado M, Dawson SJ. 1Centre for Auditory Research, Ear Institute, University College London, 332 Gray’s Inn Road, London WC1X 8EE, UK. Abstract Genetic variation in superoxide dismutase 2 (SOD2) is […]
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The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea.
Hear Res. 2006 Apr;214(1-2):1-6. The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea. Murashita H1, Tabuchi K, Hoshino T, Tsuji S, Hara A. 1Department of Otolaryngology, Tsukuba University Hospital, Tsukuba, Japan. Abstract Oxygen free radicals have been implicated in the pathogenesis of acoustic injury of the cochlea. […]
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SOD protects against oxidative stress caused by cisplatin.
Acta Otolaryngol. 2010 Apr;130(4):453-7. Endogenous protection against oxidative stress caused by cisplatin: role of superoxide dismutase. González-García JA1, Nevado J, García-Berrocal JR, Sánchez-Rodríguez C, Trinidad A, Sanz R, Ramírez-Camacho R. 1Servicio de Otorrinolaringología, Instituto Oncológico Kutxa-Onkologikoa, Paseo Dr Begiristain 119, San Sebastián, Guipúzcoa. Abstract CONCLUSION: The administration of cisplatin induces the activation of superoxide dismutase […]
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Protective effect of tempol and Nω-nitro-L-arginine methyl ester on acoustic injury,
J Pharmacol Sci. 2010;114(1):50-62. Mechanism underlying the protective effect of tempol and Nω-nitro-L-arginine methyl ester on acoustic injury: possible involvement of c-Jun N-terminal kinase pathway and connexin26 in the cochlear spiral ligament. Nagashima R1, Yamaguchi T, Tanaka H, Ogita K. 1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, Japan. Abstract […]
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Creatine and tempol attenuate noise-induced hearing loss.
Brain Res. 2007 May 7;1148:83-9. Creatine and tempol attenuate noise-induced hearing loss. Minami SB1, Yamashita D, Ogawa K, Schacht J, Miller JM. 1Kresge Hearing Research Institute, University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA. Abstract To define the role of free radical formation and potential energy depletion in noise induced hearing […]
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