Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.
PLoS One. 2014 Oct 1;9(10) Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Ahmed LA1, Shehata NI2, Abdelkader NF1, Khattab MM1. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Abstract BACKGROUND: Mitochondrial dysfunction […]
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Tempol protects the blood-brain barrier and targets intracellular ROS in cerebral malaria
PLoS One. 2014 Feb 28;9(2):e87140. Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. Francischetti IM1, Gordon E2, Bizzarro B3, Gera N2, Andrade BB4, Oliveira F1, Ma D1, Assumpção TC1, Ribeiro JM1, Pena M2, Qi CF2, Diouf A1, Moretz SE1, Long […]
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Tempol – promising therapeutic for neuroinflammatory diseases, including multiple sclerosis (MS)
Free Radic Biol Med. 2010 Mar 1;48(5):704-12. Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation. Tsuhako MH1, Augusto O, Linares E, Chadi G, Giorgio S, Pereira CA. 1Laboratório de Imunologia Viral, Instituto Butantan, 05503-900 São Paulo, Brazil. Abstract Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating […]
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SOD2 gene polymorphisms in psoriatic arthritis
Dis Markers. 2003-2004;19(6):263-5. Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. Yen JH1, Tsai WC, Lin CH, Ou TT, Hu CJ, Liu HW 1Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. jehsye@kmu.edu.tw Abstract The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms […]
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Tempol for SOD and catalase deficiency in psoriasis
Indian J Clin Biochem. 2010 Oct;25(4):388-92. Role of oxidative stress in various stages of psoriasis. Kadam DP1, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH. 1Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra India. Abstract Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous […]
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Tempol, losartan and EB1089 provided protection against DNA damaging effects of glucose and HIV.
Cell Signal. 2015 Mar;27(3):460-9. Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors. Rai P1, Singh T1, Lederman R1, Chawla A1, Kumar D1, Cheng K1, Valecha G1, Mathieson PW1, Saleem MA1, Malhotra A1, Singhal PC2. 1Department of Medicine, Feinstein Institute for Medical Research, North Shore LIJ Medical School, NY, USA; Department […]
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Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Cancer Res. 2008 Mar 1;68(5):1601-8. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Zhang QS1, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M. 1Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA. Abstract Fanconi anemia (FA) is a […]
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Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.
Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure. Summary Skin cancer is the […]
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TEMPOL for Cancer
TEMPOL for Cancer– Why Treat Fibrocystic Change? Jan 11, 2015 Peter H Proctor, PhD, MD TEMPOL is a small-molecule “SOD-mimetic”, effective in a variety of experimental cancer models, both in vivo and in vitro. Tracing back to the Warburg effect, its putative mechanism of action is destruction of reactive oxygen species (ROS). These drive the […]
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Tempol restores erectile dysfunction in diabetic models
J Urol. 2009 Nov;182(5):2518-25. Restoring erectile function by antioxidant therapy in diabetic rats. Hirata H1, Kawamoto K, Kikuno N, Kawakami T, Kawakami K, Saini S, Yamamura S, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs Medical Center and University of California-San Francisco, California 94121, USA. Abstract PURPOSE: Diabetes mediates an increase in reactive oxygen […]
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