Tempol restores erectile function in diabetes-induced impotence.
Int J Impot Res. 2009 Nov-Dec;21(6):348-55. Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. Kawakami T1, Urakami S, Hirata H, Tanaka Y, Nakajima K, Enokida H, Shiina H, Ogishima T, Tokizane T, Kawamoto K, Miura K, Ishii N, Dahiya R. 1Department of Urology, San Francisco Veterans Affairs […]
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Mitochondrial antioxidants Tempol and EUK-134 effect in neurodegenerative diseases without the need of liposomes.
Eur J Pharmacol. 2002 Jul 5;447(2-3):155-61. Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases? Dessolin J1, Schuler M, Quinart A, De Giorgi F, Ghosez L, Ichas F. 1European Institute of Chemistry and Biology and INSERM E.9929, Université Victor Segalen-Bordeaux 2, 33076 Bordeaux cedex, France. Abstract Mitochondria are the major […]
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Benefits of losartan and tempol in renal inflammation by hypernatremia.
Free Radic Res. 2015 Apr;49(4):383-96. Role of angiotensin II and oxidative stress in renal inflammation by hypernatremia: Benefits of atrial natriuretic peptide, losartan, and tempol. Della Penna SL1, Rosón MI, Toblli JE, Fernández BE. 1Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Argentina. Abstract The body regulates plasma sodium levels […]
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Tempol diminishes cocaine-induced oxidative damage
Neuroscience. 2008 Aug 26;155(3):649-58. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Numa R1, Kohen R, Poltyrev T, Yaka R. 1Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Abstract A variety of mechanisms has been suggested for cocaine toxicity, including […]
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Polymorphisms in superoxide dismutase genes in autism spectrum disorder.
Autism Res. 2014 Feb;7(1):138-44. Rare single nucleotide polymorphisms in the regulatory regions of the superoxide dismutase genes in autism spectrum disorder. Kovač J1, Macedoni Lukšič M, Trebušak Podkrajšek K, Klančar G, Battelino T. 1Department of Endocrinology, Diabetes and Metabolic Diseases, UMC Ljubljana, University Children’s Hospital, Ljubljana, Slovenia. Abstract Oxidative stress is suspected to be one […]
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Effects of tempol and redox-cycling nitroxides in models of oxidative stress.
Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]
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Tempol ameliorates ROS and apnea-induced hypertension.
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2971-6. Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Troncoso Brindeiro CM1, da Silva AQ, Allahdadi KJ, Youngblood V, Kanagy NL. 1Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA. Abstract In clinical studies, sleep apnea is associated with hypertension, oxidative […]
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Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.
Am J Respir Cell Mol Biol. 2012 Feb;46(2):139-48. Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Skelly JR1, Edge D, Shortt CM, Jones JF, Bradford A, O’Halloran KD. 1Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. Abstract Respiratory muscle dysfunction is implicated in the […]
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Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]
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The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]
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