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Tag Archives: Animal

Effects of tempol and redox-cycling nitroxides in models of oxidative stress.

Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]

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Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.

Acta Physiol Scand Suppl. 1980;492:59-65.  Chromosome instability in human and murine autoimmune disease: anticlastogenic effect of superoxide dismutase.  Emerit I, Michelson AM.   Abstract Increased chromosome breakage is observed in lymphocyte cultures from patients with so-called autoimmune diseases also in the animal model, the NZB mouse. A clastogenic agent was detected in the serum of […]

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Tempol Moderately Extends Survival in a hSOD1G93A ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1G93A Forms

PLoS One. 2013; 8(2): e55868. Linares E¹, Seixas LV, dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O. ¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms […]

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Tempol reduces oxidative stress, improves insulin sensitivity.

Diabetes. 2005 Jul;54(7):2219-26. Banday AA¹, Marwaha A, Tallam LS, Lokhandwala MF. ¹Heart and Kidney Institute, University of Houston, Houston, Texas Abstract Oxidative stress plays a pathogenic role in hypertension, particularly the one associated with diabetes and obesity. Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by […]

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