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Tag Archives: Ataxia Telangiectasia/genetics

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Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.

Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]

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Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.

Hum Mol Genet. 2005 Jun 15;14(12):1699-708. Epub 2005 May 11. Erker L¹, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A. ¹Department of Pediatrics, UCSD School of Medicine, La Jolla, CA Abstract We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient […]

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