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Tag Archives: Cell Line

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Tempol is synthetically lethal with a BRCA1-deficiency in breast cancer cells

Cell Cycle. 2012 Dec 1;11(23):4402-13. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Martinez-Outschoorn UE1, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, Pavlides S, Lamb R, Sneddon S, Howell A, Sotgia F, Lisanti MP. 1Jefferson Stem Cell Biology and Regenerative Medicine […]

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WR-1065 and Tempol protected MOLT-3 cells against specific types of AZT-induced DNA damage.

Environ Mol Mutagen. 2014 Aug;55(7):566-72. Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and Tempol. Olivero OA1, Ongele MO, Braun HM, Marrogi A, Divi K, Mitchell JB, Poirier MC. 1Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Abstract The cytokinesis-block […]

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