Pharmacol Ther. 2010 May;126(2):119-45. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Wilcox CS1. 1Division of Nephrology and Hypertension, Department of Medicine and Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC, United States. Abstract Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) […]Take a Tour
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2971-6. Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Troncoso Brindeiro CM1, da Silva AQ, Allahdadi KJ, Youngblood V, Kanagy NL. 1Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA. Abstract In clinical studies, sleep apnea is associated with hypertension, oxidative […]Take a Tour
Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia.
Am J Respir Cell Mol Biol. 2012 Feb;46(2):139-48. Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Skelly JR1, Edge D, Shortt CM, Jones JF, Bradford A, O’Halloran KD. 1Department of Physiology, University College Cork, Western Gateway Building, Western Road, Cork, Ireland. Abstract Respiratory muscle dysfunction is implicated in the […]Take a Tour
Hum Mol Genet. 2004 Aug 15;13(16):1793-802 Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Schubert R1, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A. 1Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093-0627, USA. Abstract Reactive oxygen species (ROS) are important endogenous […]Take a Tour
The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.
Mol Cancer. 2006 Jun 6;5:21. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Lejeune D1, Hasanuzzaman M, Pitcock A, Francis J, Sehgal I. 1LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. DLeJeune@vetmed.lsu.edu Abstract There is little understanding of the effect that reactive oxygen […]Take a Tour
Am J Pathol. 2003 Nov;163(5):1997-2008. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. El-Remessy AB1, Khalil IE, Matragoon S, Abou-Mohamed G, Tsai NJ, Roon P, Caldwell RB, Caldwell RW, Green K, Liou GI. 1Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. Abstract […]Take a Tour
Tempol promising for retinitis pigmentosa as increased expression of catalase and superoxide dismutase 2 reduces cone cell death.
Mol Ther. 2009 May;17(5):778-86. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S1, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA. 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, […]Take a Tour
TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.
Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]Take a Tour
Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors.
J Heart Lung Transplant. 2008 Aug;27(8):890-7. doi: 10.1016/j.healun.2008.05.019. Epub 2008 Jul 3. Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors. Hodyc D1, Hnilickova O, Hampl V, Herget J. 1Department of Physiology, Second Medical School, Charles University of Prague, Prague, Czech Republic. BACKGROUND: Lungs retrieved […]Take a Tour
Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection. [Article in Polish]
Postepy Hig Med Dosw (Online). 2011 Feb 2;65:46-54. [Article in Polish] Tabaczar S¹, Talar M, Gwoździński K. Abstract Nitroxides as stabile organic radicals were used initially as spin labels in spectroscopy of electron paramagnetic resonance (EPR) with respect to parameters such as pH of an intercellular environment, oxygenation of cells and tissues, fluidity of biological membranes, […]Take a Tour