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Tag Archives: free radicals

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The role of redox balance in vascular dysfunction and chronic obstructive pulmonary disease.

Hypertension. 2014 Mar;63(3):459-67. Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance. Ives SJ1, Harris RA, Witman MA, Fjeldstad AS, Garten RS, McDaniel J, Wray DW, Richardson RS. 1VA Medical Center Bldg 2, Rm 1D25, 500 Foothill Dr, Salt Lake City, UT 84148. Abstract Chronic obstructive pulmonary disease (COPD) is characterized by […]

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Tempol mitigates C-reactive protein induced retinal damage.

Invest Ophthalmol Vis Sci. 2008 May;49(5):2053-60. C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Nagaoka T1, Kuo L, Ren Y, Yoshida A, Hein TW. 1Department of Ophthalmology, Scott & White Eye Institute, Temple, TX 76504, USA. Abstract PURPOSE: Elevated levels of C-reactive protein (CRP), a proinflammatory marker, are associated […]

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Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model.

Toxicol Sci. 2012 Oct;129(2):411-20. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Solesio ME1, Saez-Atienzar S, Jordán J, Galindo MF. 1Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Abstract In the present study, the activation of autophagy and its interaction with the mitochondrial fission machinery was investigated in an experimental model […]

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Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme.

J Biol Chem. 2014 Oct 31;289(44):30690-701. Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme. Coelho FR1, Iqbal A1, Linares E1, Silva DF1, Lima FS1, Cuccovia IM1, Augusto O2. 1From the Departamento de Bioquímica, Instituto de Química, Universidade de São […]

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The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.

Free Radic Biol Med. 2014 Dec;77:168-82. The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke. Dohare P1, Hyzinski-García MC1, Vipani A1, Bowens NH1, Nalwalk JW1, Feustel PJ1, Keller RW Jr1, Jourd’heuil D2, Mongin AA3. 1Center for Neuropharmacology and Neuroscience, Albany […]

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Nitroxide stable radical suppresses autoimmune uveitis in rats.

Free Radic Biol Med. 1999 Jul;27(1-2):7-15. Zamir E¹, Zhang R, Samuni A, Kogan M, Pe’er J. ¹Department of Ophthalmology, Hadassah-Hebrew University Medical School, Jerusalem, Israel. Abstract Free radicals have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU). Nitroxides are stable radicals with a superoxide-dismutase-mimicking activity, which exert an anti-inflammatory effect in various animal […]

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Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers*

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1507-11. Fujii N1, Brunt VE1, Minson CT1 1Department of Human Physiology, The University of Oregon, Eugene, Oregon. Abstract We recently found that young cigarette smokers display cutaneous vascular dysfunction relative to non-smokers, which is partially due to reduced nitric oxide (NO) synthase (NOS)-dependent vasodilation. In this study, […]

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