Information on this site is for research purposes only.

Close Icon

Tag Archives: Mitochondria

Fluoroquinolone antibiotics quenched by Tempol

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:887-91. Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO [Tempol} in aqueous solution. Żamojć K1, Wiczk W2, Zaborowski B2, Makowski M2, Pranczk J2, Jacewicz D2, Chmurzyński L2.   1University of Gdansk, Faculty of Chemistry, Wita Stwosza 63, 80-308 Gdansk, Poland. Electronic 2University of Gdansk, Faculty of Chemistry, Wita Stwosza […]

Take a Tour 
Post Image

Cancer is a Metabolic Disease: Could a Ketogentic Diet & Tempol be the Answer?

        Nutr Metab (Lond). 2010 Jan 27;7:7. Cancer as a metabolic disease. Seyfried TN1, Shelton LM. 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Abstract Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal […]

Take a Tour 
Post Image

Tempol improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease

Synapse. 2015 Mar;69(3):128-38. 4-hydroxy tempo (Tempol) improves mitochondrial and neurobehavioral deficits in experimental model of Huntington’s disease. Sandhir R1, Mahajan N, Mehrotra A, Aggarwal A, Sunkaria A. 1Department of Biochemistry, Panjab University, Chandigarh, 160014, Punjab, India. Abstract Mitochondrial dysfunctions have been implicated in the progression of Huntington’s disease (HD). To date, several free radical scavengers […]

Take a Tour 
Post Image

Tempol inhibits mitochondrial superoxide: a novel specific anticancer treatment with reduced cytotoxic side effects

Antioxid Redox Signal. 2013 Aug 1;19(4):344-9. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR1, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor’ev IA, Dikalov SI. 1Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract It has been previously suggested that overexpression of mitochondrial superoxide dismutase (SOD) […]

Take a Tour 
Post Image

Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice.

PLoS One. 2014 Oct 1;9(10) Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. Ahmed LA1, Shehata NI2, Abdelkader NF1, Khattab MM1. 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Abstract BACKGROUND: Mitochondrial dysfunction […]

Take a Tour 

SOD and mitochondria quality control in ALS.

Brain Res. 2015 May 14 Exploring new pathways of neurodegeneration in ALS: The role of mitochondria quality control. Palomo GM1, Manfredi G2. 1Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United States. 2Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, United […]

Take a Tour 

SOD2 and GSH are critical for the cellular antioxidant defense in neurodegenerative diseases and acute brain disorders.

Neurochem Int. 2015 Jan 6. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Ruszkiewicz J1, Albrecht J2. 1Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. 2Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland. Abstract Oxidative and nitrosative stress […]

Take a Tour 

Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.

Front Cell Neurosci. 2015 Feb 17;9:41. Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS. Carrì MT1, Valle C2, Bozzo F1, Cozzolino M3. 1Department of Biology, Università di Roma Tor Vergata Rome, Italy ; Fondazione Santa Lucia, IRCCS Rome, Italy. 2Fondazione Santa Lucia, IRCCS Rome, Italy ; Institute of Cell Biology and Neurobiology, IBCN, National […]

Take a Tour 
Post Image

MnSOD, ROS, mitochondria, oxidative stress diseases and aging, superoxide theory

J Clin Biochem Nutr. 2015 Jan;56(1):1-7. A mitochondrial superoxide theory for oxidative stress diseases and aging. Indo HP1, Yen HC2, Nakanishi I3, Matsumoto K3, Tamura M4, Nagano Y4, Matsui H4, Gusev O5, Cornette R6, Okuda T6, Minamiyama Y7, Ichikawa H8, Suenaga S9, Oki M10, Sato T9, Ozawa T11, Clair DK12, Majima HJ13.   1Department of […]

Take a Tour 

Antihypertensive effect of mitochondria-targeted proxyl nitroxides.

Redox Biol. 2015;4:355-62. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Dikalova AE1, Kirilyuk IA2, Dikalov SI3. 1Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. 2Novosibirsk Institute of Organic Chemistry, Lavrentieva 9, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russia. 3Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA. […]

Take a Tour 
Visit Us On TwitterVisit Us On FacebookVisit Us On Google PlusVisit Us On YoutubeCheck Our Feed