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Tag Archives: SOD

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The mitochondrion: a perpetrator of acquired hearing loss.

Hear Res. 2013 Sep;303:12-9. The mitochondrion: a perpetrator of acquired hearing loss. Böttger EC1, Schacht J. 1Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. Abstract Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably […]

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Lecithinized superoxide dismutase as a drug for idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

Yakugaku Zasshi. 2014;134(1):69-76. Development of lecithinized superoxide dismutase as a drug for IPF [Article in Japanese] Mizushima T1. 1Department of Analytical Chemistry, Faculty of Pharmacy, Keio University. Abstract Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The […]

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Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme.

J Biol Chem. 2014 Oct 31;289(44):30690-701. Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme. Coelho FR1, Iqbal A1, Linares E1, Silva DF1, Lima FS1, Cuccovia IM1, Augusto O2. 1From the Departamento de Bioquímica, Instituto de Química, Universidade de São […]

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Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).

Pharmacol Res. 2014 Mar;81:91-102. Impellizzeri D¹, Esposito E¹, Attley J², Cuzzocrea S³. ¹Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy. ²Prismic Pharmaceuticals, Scottsdale, AZ, USA. ³Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, Messina 31-98166, Italy; Manchester Biomedical Research Centre, Manchester Royal […]

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Mitochondria-targeted antioxidants for treatment of Parkinson’s disease: Preclinical and clinical outcomes.

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease Volume 1842, Issue 8, August 2014, pp 1282–1294    Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases Jin H1, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG 1 Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA […]

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