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Tag Archives: Spin Labels

TEMPOL facilitated the development of the deep vascular layer before neural degeneration occurs in retinal degeneration (rd1) mice.

Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6 Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Fukuda S1, Ohneda O, Oshika T. 1Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan Abstract PURPOSE: To investigate the role of reactive oxygen species (ROS) in […]

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Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors.

J Heart Lung Transplant. 2008 Aug;27(8):890-7. doi: 10.1016/j.healun.2008.05.019. Epub 2008 Jul 3. Pre-arrest administration of the cell-permeable free radical scavenger tempol reduces warm ischemic damage of lung function in non-heart-beating donors. Hodyc D1, Hnilickova O, Hampl V, Herget J. 1Department of Physiology, Second Medical School, Charles University of Prague, Prague, Czech Republic. BACKGROUND: Lungs retrieved […]

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A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.

Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]

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Nitroxides as antioxidants – possibilities of their application in chemoprevention and radioprotection. [Article in Polish]

Postepy Hig Med Dosw (Online). 2011 Feb 2;65:46-54. [Article in Polish] Tabaczar S¹, Talar M, Gwoździński K. Abstract Nitroxides as stabile organic radicals were used initially as spin labels in spectroscopy of electron paramagnetic resonance (EPR) with respect to parameters such as pH of an intercellular environment, oxygenation of cells and tissues, fluidity of biological membranes, […]

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Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.

Hum Mol Genet. 2005 Jun 15;14(12):1699-708. Epub 2005 May 11. Erker L¹, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A. ¹Department of Pediatrics, UCSD School of Medicine, La Jolla, CA Abstract We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient […]

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Tempol Moderately Extends Survival in a hSOD1G93A ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1G93A Forms

PLoS One. 2013; 8(2): e55868. Linares E¹, Seixas LV, dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O. ¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms […]

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Tempol reduces oxidative stress, improves insulin sensitivity.

Diabetes. 2005 Jul;54(7):2219-26. Banday AA¹, Marwaha A, Tallam LS, Lokhandwala MF. ¹Heart and Kidney Institute, University of Houston, Houston, Texas Abstract Oxidative stress plays a pathogenic role in hypertension, particularly the one associated with diabetes and obesity. Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by […]

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Tempol Inhibits Pancreatic Cancer Cell Growth

Free Radical Biology and Medicine, Volume 49, Supplement, 2010, Pages S58 Du J¹, Olney K¹, Schrock H¹, Moser J¹, Wagner B¹, Sibenaller Z¹, Buettner G¹, Cullen J¹ ¹Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa ABSTRACT NOT AVAILABLE ONLINE – See full ARTICLE

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