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Category Archives: Xeroderma Pigmentosum

Tempol protects against UV cancer-causing mutations that occur hours after sun exposure.

Science 20 February 2015: Vol. 347 no. 6224 p. 824 Biomolecules The dark side of sunlight and melanoma John-Stephen Taylor Department of Chemistry, Washington University, St. Louis, MO 63130, USA.   Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.  Summary Skin cancer is the […]

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A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.

Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication […]

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Therapeutic and Clinical Applications of Nitroxide Compounds

Antioxid Redox Signal. 2007 Oct;9(10):1731-43. Forum Review: Therapeutic and clinical applications of nitroxide compounds. Soule BP¹, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. ¹ Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Abstract Nitroxide compounds have been used for many years as biophysical tools, but only […]

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Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome.

Brain Dev. 2005 Jan;27(1):34-8. Hayashi M¹, Araki S, Kohyama J, Shioda K, Fukatsu R. Abstract Xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are caused by a genetic defect of nucleotide excision repair mechanisms, showing cutaneous hypersensitivity to sunlight and progressive neurological disturbances. The cause of neurological abnormalities has yet to be clarified and […]

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Oxidative stress in developmental brain disorders.

Neuropathology. 2009 Feb;29(1):1-8.  Hayashi M¹. ¹Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. Abstract Oxidative stress is one of the predisposing factors in adult neurological disorders. We have examined the involvement of oxidative stress in child-onset neurodegenerative disorders, and here we review the findings from our analysis. In cases of Cockayne syndrome, […]

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Possible protective effect by SOD on UV damage in xeroderma pigmentosum (XP)

  J Invest Dermatol. 1989 Oct;93(4):506-10. Reduced superoxide dismutase activity in xeroderma pigmentosum fibroblasts. Nishigori C¹, Miyachi Y, Imamura S, Takebe H. ¹Department of Dermatology, Faculty of Medicine, Kyoto University, Japan. Abstract This study was performed in order to assess the possible protective effect of superoxide dismutase (SOD) on ultraviolet (UV) damage in xeroderma pigmentosum […]

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